Change search
ReferencesLink to record
Permanent link

Direct link
Development, evaluation and application of tripeptidyl-peptidase II sequence signatures
Department of Biochemistry and Organic Chemistry, Uppsala University. (Hellgren Kotaleski Lab)
2009 (English)In: Archives of Biochemistry and Biophysics, ISSN 0003-9861, E-ISSN 1096-0384, Vol. 484, no 1, 39-45 p.Article in journal (Refereed) Published
Abstract [en]

Tripeptidyl-peptidase II (TPP II) is a cytosolic peptidase that has been implicated in fat formation and cancer, apparently independent of the enzymatic activity. In search for alternative functional regions, conserved motifs were identified and eleven signatures were constructed. Seven of the signatures covered previously investigated residues, whereas the functional importance of the other motifs is unknown. This provides directions for future investigations of alternative activities of TPP II. The obtained signatures provide an efficient bioinformatic tool for the identification of TPP II homologues. Hence, a TPP II sequence homologue from fission yeast, Schizosaccharomyces pombe, was identified and demonstrated to encode the TPP II-like protein previously reported as multicorn. Furthermore, an homologous protein was found in the prokaryote Blastopirellula marina, albeit the TPP II function was apparently not conserved. This gene is probably the result of a rare gene transfer from eukaryote to prokaryote.

Place, publisher, year, edition, pages
2009. Vol. 484, no 1, 39-45 p.
Keyword [en]
Serine protease, Subtilase, Sequence motif, Cytosolic protein degradation, Tripeptidyl-peptidase II
National Category
Biological Sciences
URN: urn:nbn:se:kth:diva-53381DOI: 10.1016/ 000264927700006PubMedID: 19467630OAI: diva2:470023
QC 20111228Available from: 2011-12-28 Created: 2011-12-28 Last updated: 2011-12-28Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Gutierrez Arenas, Omar
In the same journal
Archives of Biochemistry and Biophysics
Biological Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 42 hits
ReferencesLink to record
Permanent link

Direct link