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The synaptic NMDA component desynchronizes neural bursters
KTH, School of Computer Science and Communication (CSC), Computational Biology, CB.ORCID iD: 0000-0002-0550-0739
1999 (English)In: Neurocomputing, ISSN 0925-2312, Vol. 26-27, 557-563 p.Article in journal (Refereed) Published
Abstract [en]

The influence of excitatory and inhibitory coupling on synchronization depends on the temporal dynamics of the synapse. Slow excitation is desynchronizing whereas fast excitation tends to synchronize neuronal firing. Excitation via glutamatergic synapses, however, activates both ionotropic AMPA/kainate and NMDA receptors. Here we analyze the role of the synaptic NMDA component. We show that slowly bursting neurons desynchronize when connected by symmetrical NMDA synapses whereas they tend to synchronize when coupled with symmetrical AMPA/kainate synapses. This suggests that the effect on synchronization of an excitatory synapse also depends on the relative proportion of NMDA and AMPA/kainate synapses.

Place, publisher, year, edition, pages
1999. Vol. 26-27, 557-563 p.
Keyword [en]
Synchronization; Bursters; Slow variable; Calcium
National Category
Computer and Information Science
URN: urn:nbn:se:kth:diva-58746DOI: diva2:473927
NR 20140805Available from: 2012-01-08 Created: 2012-01-08Bibliographically approved

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Hellgren Kotaleski, Jeanette
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