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GABAergic control of dendritic calcium dynamics in striatal medium spiny neurons
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2008 (English)Conference paper, Published paper (Refereed)
Abstract [en]

Experiments have demonstrated the ability of action potentials to actively backpropagate in striatal medium spiny (MS) neurons, affecting the calcium levels in the dendrites [1, 2, 3]. Increased calcium levels trigger changes in plasticity [4, 5], which is important for learning and other functions [6]. Studies in the hippocampus have shown that GABAergic input can modulate the backpropagation of action potentials from the soma to the distal dendrites [7]. The MS neurons receive both proximal feedforward GABAergic inhibition from fast spiking interneurons (FS), and distal feedback inhibition from other neighbouring MS neurons. In the present study the effect of GABAergic inputs on the dendritic calcium dynamics is investigated.

Place, publisher, year, edition, pages
2008.
National Category
Computer and Information Science
Identifiers
URN: urn:nbn:se:kth:diva-58771DOI: 10.3389/conf.neuro.11.2008.01.044OAI: oai:DiVA.org:kth-58771DiVA: diva2:473965
Conference
1st INCF Congress of Neuroinformatics
Note
QC 20120119Available from: 2012-01-08 Created: 2012-01-08 Last updated: 2012-01-19Bibliographically approved

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Hellgren Kotaleski, Jeanette

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