Modeling of the receptor, G-protein and effector reactions in vertebrate olfactory receptor neurons
2008 (English)Conference paper (Refereed)
A biochemical model is developed for the receptor, G-protein and effector (RGE) steps of olfactory signal transduction in the cilia of the vertebrate olfactory receptor neurons (ORNs). It describes the steps from odorant binding to activation of the effector enzyme, which catalyzes the conversion of ATP to cAMP. In the cilia of the olfactory receptor neurons (ORNs), cAMP regulates cyclic nucleotide gated channels, which in turn control Ca influx and Ca dependent activation of chloride conductances. As a result the cilia potential becomes depolarized.
Place, publisher, year, edition, pages
Computer and Information Science
IdentifiersURN: urn:nbn:se:kth:diva-58773DOI: 10.1186/1471-2202-9-S1-O10OAI: oai:DiVA.org:kth-58773DiVA: diva2:473969
QC 201201112012-01-082012-01-082012-01-11Bibliographically approved