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Modeling of the receptor, G-protein and effector reactions in vertebrate olfactory receptor neurons
KTH, School of Computer Science and Communication (CSC), Computational Biology, CB.
KTH, School of Computer Science and Communication (CSC), Computational Biology, CB.
KTH, School of Computer Science and Communication (CSC), Computational Biology, CB.ORCID iD: 0000-0002-0550-0739
2008 (English)Conference paper, Published paper (Refereed)
Abstract [en]

A biochemical model is developed for the receptor, G-protein and effector (RGE) steps of olfactory signal transduction in the cilia of the vertebrate olfactory receptor neurons (ORNs). It describes the steps from odorant binding to activation of the effector enzyme, which catalyzes the conversion of ATP to cAMP. In the cilia of the olfactory receptor neurons (ORNs), cAMP regulates cyclic nucleotide gated channels, which in turn control Ca influx and Ca dependent activation of chloride conductances. As a result the cilia potential becomes depolarized.

Place, publisher, year, edition, pages
2008.
National Category
Computer and Information Science
Identifiers
URN: urn:nbn:se:kth:diva-58773DOI: 10.1186/1471-2202-9-S1-O10OAI: oai:DiVA.org:kth-58773DiVA: diva2:473969
Conference
CNS 2008
Note
QC 20120111Available from: 2012-01-08 Created: 2012-01-08 Last updated: 2012-01-11Bibliographically approved

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Hellgren Kotaleski, Jeanette

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