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GABAergic control of backpropagating action potentials in striatal medium spiny neurons
KTH, School of Computer Science and Communication (CSC), Computational Biology, CB.
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2008 (English)Conference paper (Refereed)
Abstract [en]

Experiments have demonstrated the ability of action potentials to actively backpropagate in striatal medium spiny (MS) neurons, affecting the calcium levels in the dendrites[1-3]. Increased calcium levels trigger changes in plasticity[4,5], which is important for learning and other functions[6]. Studies in the hippocampus have shown that GABAergic input can modulate the backpropagation of action potentials from the soma to the distal dendrites[7]. The MS neurons receive both proximal feedforward GABAergic inhibition from fast spiking interneurons (FS), and distal feedback inhibition from other neighbouring MS neurons. In the present study the effect of these GABAergic inputs on the dendritic calcium dynamics is investigated.

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Computer and Information Science
URN: urn:nbn:se:kth:diva-58774DOI: 10.1186/1471-2202-9-S1-P105OAI: diva2:473970
CNS 2008
QC 20120119Available from: 2012-01-08 Created: 2012-01-08 Last updated: 2012-01-19Bibliographically approved

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Hjorth, JohannesHellgren Kotaleski, Jeanette
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Computational Biology, CB
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