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Platelet-derived growth factor inhibition: a new treatment of pulmonary hypertension in congenital diaphragmatic hernia?
Karolinska Institutet.ORCID iD: 0000-0002-8987-9909
2008 (English)In: Journal of Pediatric Surgery, ISSN 0022-3468, E-ISSN 1531-5037, Vol. 43, no 10, 1928-1931 p.Article in journal (Refereed) Published
Abstract [en]

Increased pulmonary vascular resistance causing pulmonary artery hypertension is a major problem in the treatment of congenital diaphragmatic hernia with a strong association to mortality. We here report a patient with intractable pulmonary hypertension at 4 weeks of age unresponsive to conventional treatment. After administration of the platelet-derived growth factor (PDGF) receptor antagonist imatinib, pulmonary artery pressure gradually decreased to acceptable levels and the patient's clinical condition gradually improved.

Place, publisher, year, edition, pages
2008. Vol. 43, no 10, 1928-1931 p.
Keyword [en]
Anoxia/drug therapy/etiology/therapy, Combined Modality Therapy, Continuous Positive Airway Pressure, Diuretics/therapeutic use, Enteral Nutrition, Extracorporeal Membrane Oxygenation, Heart Failure/etiology, Hernia, Diaphragmatic/*complications/congenital/surgery, Humans, Hypertension, Pulmonary/*drug therapy/etiology, Iloprost/therapeutic use, Infant, Newborn, Male, Nitric Oxide/therapeutic use, Piperazines/*therapeutic use, Protein Kinase Inhibitors/*therapeutic use, Purines/therapeutic use, Pyrimidines/*therapeutic use, Receptors, Platelet-Derived Growth Factor/*antagonists & inhibitors, Sulfonamides/therapeutic use, Sulfones/therapeutic use
National Category
Anesthesiology and Intensive Care
URN: urn:nbn:se:kth:diva-58864DOI: 10.1016/j.jpedsurg.2008.07.022ISI: 000260359300031ISBN: 1531-5037 (Electronic) 0022-3468 (Linking)OAI: diva2:474815
QC 20120110Available from: 2012-01-10 Created: 2012-01-09 Last updated: 2012-01-10Bibliographically approved

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Broomé, Michael
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