Intracoronary beta2 receptor activation induces dynamic local t-PA release in the pig
2003 (English)Other (Refereed)
To investigate beta2 -adrenergic agonist-mediated effects on coronary fluxes of local fibrinolytic factors, healthy anaesthetised and instrumented pigs (n=10) were studied during infusion of isoprenaline (IPR) into the left main coronary artery. Coronary net fluxes of total t-PA antigen, active t-PA and total PAI-1 antigen were determined at baseline and at 3, 5, 7 and 10 minutes of IPR infusion. During IPR, net release of total t-PA increased in a biphasic pattern with transiently high levels at 3 (+440 %) and 7 minutes (+620%) and returned towards baseline at 10 minutes. Net coronary release of active t-PA increased with maximum levels at 3 minutes (+50%). Baseline coronary net flux of total PAI -1 showed a decrease which was most pronounced at 10 minutes. To conclude, a fast beta2 agonist-mediated local release of t-PA into the coronary vasculature was demonstrated. For total t-PA, this response was characterised by a biphasic release profile.
Place, publisher, year, edition, pages
Adrenergic Agonists/*pharmacology, Adrenergic beta-2 Receptor Agonists, Animals, Catheterization, Coronary Vessels/*metabolism/physiology, Female, Fibrinolysis, Hemodynamics/drug effects, Isoproterenol/pharmacology, Kinetics, Plasminogen Activator Inhibitor 1/blood, Receptors, Adrenergic, beta-2/*blood, Swine, Tissue Plasminogen Activator/*blood
Anesthesiology and Intensive Care
IdentifiersURN: urn:nbn:se:kth:diva-58861ISBN: 0340-6245 (Print) 0340-6245 (Linking)OAI: oai:DiVA.org:kth-58861DiVA: diva2:474818
Osterlund, Barbro Jern, Christina Seeman-Lodding, Helene Johansson, Goran Haggmark, Soren Broome, Michael Biber, Bjorn Research Support, Non-U.S. Gov't Germany Thrombosis and haemostasis Thromb Haemost. 2003 Nov;90(5):796-802. NR 201408052012-01-102012-01-092012-01-10Bibliographically approved