Simulation of Cardiovascular Physiology and Pathology: The Effects of Mitral Regurgitation on Mitral and Pulmonary Venous Flow
2004 (English)Other (Other academic)
Background: The development of simulation models and modern computers makes it possible to simulate both normal cardiovascular physiology and pathology realistically. These models can be used to aid clinicians and researchers in understanding complex phenomenon. Methods: An electrical analogue of the cardiovascular system consisting of resistances, capacitances and inductances has been constructed. The contractile function of the cardiac atria and ventricles area represented by time-varying elastances. Valvular function, pericardial volume, ventricular interaction and intrathoracic pressure are also represented by constants and functions interacting with the rest of the model. Results: A regurgitant mitral orifice of 1 cm2 during systole results in an increased volume load on the left ventricle, a decrease in cardiac output and systemic arterial blood pressures accompanied by an increase in left and right-sided cardiac filling pressures and volumes. A systolic reversal of flow in the pulmonary veins is seen. The magnitude of systolic flow reversal in the pulmonary veins is dependent on left atrial compliance. Conclusion: Simulation of cardiac normal function and pathology is a meaningful way to study the heart. Results from simulations can be used to interpret clinical invasive monitoring and echocardiography data as well as experimental research data. Left atrial compliance may be of importance for interpretation of pulmonary venous flow profiles in mitral regurgitation.
Place, publisher, year, edition, pages
Cardiac and Cardiovascular Systems
IdentifiersURN: urn:nbn:se:kth:diva-58843OAI: oai:DiVA.org:kth-58843DiVA: diva2:474823
QC 201502182012-01-102012-01-092015-02-18Bibliographically approved