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Microfabricated Device for Controlled Stimuli of Primary Cilia
KTH, School of Electrical Engineering (EES), Microsystem Technology.ORCID iD: 0000-0001-9552-4234
KTH, School of Engineering Sciences (SCI), Applied Physics, Cell Physics.
KTH, School of Electrical Engineering (EES), Microsystem Technology.ORCID iD: 0000-0002-3996-9279
KTH, School of Biotechnology (BIO), Nano Biotechnology.
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2006 (English)In: Proceedings of the 10th International Conference in Miniaturized Systems for Chemistry and Life Sciences (µTas), 2006, 1510-1512 p.Conference paper, Published paper (Refereed)
Abstract [en]

We present an improved device and method for studying cellular response onmicrofluidic controlled stimuli of primary cilia. The primary cilium functions as amechano-sensor in renal tubular epithelium. Malfunction of cilia has been implicated inpolycystic kidney decease as well as other kidney abnormalities. Bending of cilia willgive rise to an intracellular calcium signal [1,2,3], but little is known about theimportance of flow direction, magnitude and duration to the calcium response. Ourpreliminary results indicate flow speed sensitivity.

Place, publisher, year, edition, pages
2006. 1510-1512 p.
National Category
Engineering and Technology
Identifiers
URN: urn:nbn:se:kth:diva-60711Scopus ID: 2-s2.0-84902532154OAI: oai:DiVA.org:kth-60711DiVA: diva2:477779
Conference
Micro Total Analysis Systems (µTas) 2006. Tokyo, Japan, Nov 5-9, 2006
Note
QC 20120116Available from: 2012-01-13 Created: 2012-01-13 Last updated: 2012-01-16Bibliographically approved

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Stemme, GöranBrismar, Hjalmar

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