Microfabricated Device for Controlled Stimuli of Primary Cilia
2006 (English)In: Proceedings of the 10th International Conference in Miniaturized Systems for Chemistry and Life Sciences (µTas), 2006, 1510-1512 p.Conference paper (Refereed)
We present an improved device and method for studying cellular response onmicrofluidic controlled stimuli of primary cilia. The primary cilium functions as amechano-sensor in renal tubular epithelium. Malfunction of cilia has been implicated inpolycystic kidney decease as well as other kidney abnormalities. Bending of cilia willgive rise to an intracellular calcium signal [1,2,3], but little is known about theimportance of flow direction, magnitude and duration to the calcium response. Ourpreliminary results indicate flow speed sensitivity.
Place, publisher, year, edition, pages
2006. 1510-1512 p.
Engineering and Technology
IdentifiersURN: urn:nbn:se:kth:diva-60711ScopusID: 2-s2.0-84902532154OAI: oai:DiVA.org:kth-60711DiVA: diva2:477779
Micro Total Analysis Systems (µTas) 2006. Tokyo, Japan, Nov 5-9, 2006
QC 201201162012-01-132012-01-132012-01-16Bibliographically approved