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Estimating the variation in S phase duration from flow cytometric histograms
Lund University.
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2008 (English)In: Mathematical Biosciences, ISSN 0025-5564, E-ISSN 1879-3134, Vol. 213, no 1, 40-49 p.Article in journal (Refereed) Published
Abstract [en]

A stochastic model for interpreting BrdUrd DNA FCM-derived data is proposed. The model is based on branching processes and describes the progression of the DNA distribution of BrdUrd-labelled cells through the cell cycle. With the main focus on estimating the S phase duration and its variation, the DNA replication rate is modelled by a piecewise linear function, while assuming a gamma distribution for the S phase duration. Estimation of model parameters was carried out using maximum likelihood for data from two different cell lines. The results provided quite a good fit to the data, suggesting that stochastic models may be a valuable tool for analysing this kind of data.

Place, publisher, year, edition, pages
2008. Vol. 213, no 1, 40-49 p.
Keyword [en]
branching process, cell cycle progression, S phase duration, flow cytometry
National Category
Probability Theory and Statistics Cell Biology
Identifiers
URN: urn:nbn:se:kth:diva-61474DOI: 10.1016/j.mbs.2008.01.009ISI: 000256231600005OAI: oai:DiVA.org:kth-61474DiVA: diva2:479187
Note
QC 20120118Available from: 2012-01-17 Created: 2012-01-17 Last updated: 2017-12-08Bibliographically approved

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