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Covalent VEGF protein immobilization on resorbable polymeric surfaces
KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology, Polymer Technology.ORCID iD: 0000-0002-1631-1781
KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology, Polymer Technology.
KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology, Polymer Technology.
2011 (English)In: Polymers for Advanced Technologies, ISSN 1042-7147, E-ISSN 1099-1581, Vol. 22, no 12, 2368-2373 p.Article in journal (Refereed) Published
Abstract [en]

Vascular endothelial growth factor type protein (VEGF), a potent angiogenic effector molecule, was successfully covalently immobilized onto the surfaces of the resorbable polymers poly(L-lactic acid) (PLLA) and poly(epsilon-caprolactone) (PCL) through a three-step strategy. The surfaces were first covalently grafted with poly(acrylic acid) using non-destructive and solvent free vapor-phase grafting. A diamine spacer was coupled to the carboxylic acid pendant groups on the graft chains using EDC/NHS chemistry and VEGF was finally covalently attached to the amine linkers. The chemistry and topography of the modified substrates were quantitatively and qualitatively verified with XPS, ATR-FTIR, UV-VIS, SEM, and ELISA.

Place, publisher, year, edition, pages
2011. Vol. 22, no 12, 2368-2373 p.
Keyword [en]
polylactide, poly(epsilon-caprolactone), vapor phase grafting, VEGF, surface
National Category
Polymer Technologies
Identifiers
URN: urn:nbn:se:kth:diva-63268DOI: 10.1002/pat.1772ISI: 000298175400106OAI: oai:DiVA.org:kth-63268DiVA: diva2:483514
Note
QC 20120123Available from: 2012-01-25 Created: 2012-01-23 Last updated: 2017-12-08Bibliographically approved

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Edlund, Ulrica

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