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Covalent VEGF protein immobilization on resorbable polymeric surfaces
KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology, Polymer Technology.ORCID iD: 0000-0002-1631-1781
KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology, Polymer Technology.
KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology, Polymer Technology.ORCID iD: 0000-0001-8696-9143
2011 (English)In: Polymers for Advanced Technologies, ISSN 1042-7147, E-ISSN 1099-1581, Vol. 22, no 12, p. 2368-2373Article in journal (Refereed) Published
Abstract [en]

Vascular endothelial growth factor type protein (VEGF), a potent angiogenic effector molecule, was successfully covalently immobilized onto the surfaces of the resorbable polymers poly(L-lactic acid) (PLLA) and poly(epsilon-caprolactone) (PCL) through a three-step strategy. The surfaces were first covalently grafted with poly(acrylic acid) using non-destructive and solvent free vapor-phase grafting. A diamine spacer was coupled to the carboxylic acid pendant groups on the graft chains using EDC/NHS chemistry and VEGF was finally covalently attached to the amine linkers. The chemistry and topography of the modified substrates were quantitatively and qualitatively verified with XPS, ATR-FTIR, UV-VIS, SEM, and ELISA.

Place, publisher, year, edition, pages
2011. Vol. 22, no 12, p. 2368-2373
Keywords [en]
polylactide, poly(epsilon-caprolactone), vapor phase grafting, VEGF, surface
National Category
Polymer Technologies
Identifiers
URN: urn:nbn:se:kth:diva-63268DOI: 10.1002/pat.1772ISI: 000298175400106Scopus ID: 2-s2.0-78650722403OAI: oai:DiVA.org:kth-63268DiVA, id: diva2:483514
Note
QC 20120123Available from: 2012-01-25 Created: 2012-01-23 Last updated: 2020-03-10Bibliographically approved

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Edlund, Ulrica

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