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Non-immunoglobulin based protein scaffolds
KTH, School of Biotechnology (BIO), Molecular Biotechnology.ORCID iD: 0000-0001-9423-0541
Uppsala University.
KTH, School of Biotechnology (BIO), Molecular Biotechnology.ORCID iD: 0000-0002-9282-0174
2011 (English)In: Current Opinion in Biotechnology, ISSN 0958-1669, E-ISSN 1879-0429, Vol. 22, no 6, 843-848 p.Article, review/survey (Refereed) Published
Abstract [en]

Non-immunoglobulin based protein scaffolds have been reported as promising alternatives to traditional monoclonal antibodies for over a decade and are often mentioned as part of the next-generation immunotherapeutics. Today, this class of biologics is beginning to demonstrate its potential for therapeutic applications and several are currently in preclinical or clinical development. A common denominator for most of these new scaffolds is the attractive properties that differentiate them from monoclonal antibodies including small size, cysteine-free sequence, flexible pharmacokinetic properties, and ease of generating multispecific molecules. In addition to therapeutic applications, substantial evidence point to superior performance of several of these scaffolds in molecular imaging compared to full-length antibodies. Here we review the most recent progress using alternative protein scaffolds for therapy and medical imaging.

Place, publisher, year, edition, pages
2011. Vol. 22, no 6, 843-848 p.
National Category
Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)
Identifiers
URN: urn:nbn:se:kth:diva-63267DOI: 10.1016/j.copbio.2011.06.002ISI: 000298523700014Scopus ID: 2-s2.0-80053438315OAI: oai:DiVA.org:kth-63267DiVA: diva2:483519
Note
QC 20120125Available from: 2012-01-25 Created: 2012-01-23 Last updated: 2017-12-08Bibliographically approved

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Löfblom, JohnStåhl, Stefan

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