Molecular Structural Differences between Type-2-Diabetic and Healthy Glycogen
2011 (English)In: Biomacromolecules, ISSN 1525-7797, E-ISSN 1526-4602, Vol. 12, no 6, 1983-1986 p.Article in journal (Refereed) Published
Glycogen is a highly branched glucose polymer functioning as a glucose buffer in animals. Multiple-detector size exclusion chromatography and fluorophore-assisted carbohydrate electrophoresis were used to examine the structure of undegraded native liver glycogen (both whole and enzymatically del;ranched) as a function of molecular size, isolated from the liver; of healthy and db/db mice (the latter a type 2 diabetic model). Both the fully branched and debranched levels of glycogen structure showed fundamental differences between glycogen from healthy and db/db mice. Healthy glycogen had a greater population of large particles, with more a particles (tightly linked assemblages of smaller,8 particles) than glycogen from db/db mice. These structural differences suggest a new understanding of type 2 diabetes.
Place, publisher, year, edition, pages
2011. Vol. 12, no 6, 1983-1986 p.
Biochemistry and Molecular Biology
IdentifiersURN: urn:nbn:se:kth:diva-48782DOI: 10.1021/bm2006054ISI: 000291499900004OAI: oai:DiVA.org:kth-48782DiVA: diva2:484232
QC 201201272012-01-262011-11-232012-01-27Bibliographically approved