Investigating the Role of Smooth Muscle in Carotid Arteries: A Finite Element Analysis
(English)Article in journal (Other academic) Submitted
Vascular smooth muscle is a slow muscle, which reach isometric active steady-state force within minutes and it is not well known how this influence the active response in arteries that are loaded to cardiac pressure cycles that act within seconds. The role of active smooth muscle in larger arteries was investigated by studying how changes in intracellular calcium and medial wall thickness affect the deformation and transmural circumferential stress in arteries when loaded with cardiac pressure pulses. A three-dimensional finite element model of a two-layer carotid arterial ring was constructed using an implemented mechanochemical model of the active smooth muscle, which couples intracellular calcium to mechanical contraction together with a hyperelastic anisotropic model representing the elastin and collagen in the arterial ring. The material parameters was taken from previous work fitted to swine carotid artery. Residual stresses and strain in arterial ring were considered by closing an initial opening angle in the arterial ring. The simulation results of the arterial ring exposed to realistic pressure pulses and varying intracellular calcium waves with same period as the pressure pulses, showed that changes in intracellular calcium amplitudes did not have significant impact on the radial deformation and the transmural stress of the arterial ring. Increase in the mean value of the intracellular calcium waves as well as in the medial wall thickness showed to have a more significant effect on the behavior of the arterial wall.
IdentifiersURN: urn:nbn:se:kth:diva-66778OAI: oai:DiVA.org:kth-66778DiVA: diva2:484617
QS 2012. QS 201203282012-01-272012-01-272012-03-28Bibliographically approved