Linear-Dendritic Polymeric Amphiphiles as Carriers of Doxorubicin-In Vitro Evaluation of Biocompatibility and Drug Delivery
2012 (English)In: Journal of Polymer Science Part A: Polymer Chemistry, ISSN 0887-624X, E-ISSN 1099-0518, Vol. 50, no 2, 217-226 p.Article in journal (Refereed) Published
In our recent work, we have explored the formation of chemotherapeutic delivery vehicles constructed from four different amphiphilic linear-dendritic hybrid block copolymers. These micelles were found to form about 100-nm-sized structures that were capable of sequestering doxorubicin at loading efficiencies up to 22%. Here, the cellular toxicity of these biocompatible and biodegradable linear-dendritic hybrid materials was evaluated on two breast cancer cell lines and primary human macrophages. The micelles were found not to affect the cellular viability at concentrations below 35 mu g mL(-1). After drug loading, these constructs could deliver an efficient dose of drugs, resulting in significant decreases in cell viability. Kinetic studies indicated that the drug formulation in the poly-mer micelles slowed down the cell uptake compared with the nonformulated drug, but similar efficacy in viability reduction and cell apoptosis were found. Taken together, these linear-dendritic hybrid materials represent an interesting novel architecture for the construction of drug delivery systems. (C) 2011 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 50: 217-226, 2012
Place, publisher, year, edition, pages
Wiley-Blackwell, 2012. Vol. 50, no 2, 217-226 p.
block copolymers, breast cancer, delivery vehicle, dendrimers, doxorubicin, drug delivery systems, linear dendrimer, primary macrophages
IdentifiersURN: urn:nbn:se:kth:diva-70023DOI: 10.1002/pola.25008ISI: 000298479300003ScopusID: 2-s2.0-83455201299OAI: oai:DiVA.org:kth-70023DiVA: diva2:485772
QC 201201302012-01-302012-01-302012-01-30Bibliographically approved