Change search
ReferencesLink to record
Permanent link

Direct link
Hyperbranched Copolymer Micelles as Delivery Vehicles of Doxorubicin in Breast Cancer Cells
KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology.
Show others and affiliations
2012 (English)In: Journal of Polymer Science Part A: Polymer Chemistry, ISSN 0887-624X, E-ISSN 1099-0518, Vol. 50, no 2, 280-288 p.Article in journal (Refereed) Published
Abstract [en]

Four types of drug nanoparticles (NPs) based on amphiphilic hyperbranched block copolymers were developed for the delivery of the chemotherapeutic doxorubicin (DOX) to breast cancer cells. These carriers have their hydrophobic interior layer composed of the hyperbranched aliphatic polyester, Boltorn (R) H30 or Boltorn (R) H40, that are polymers of poly 2,2-bis (methylol) propionic acid (bis-MPA), while the outer hydrophilic shell was composed of about 5 poly(ethylene glycol) (PEG) segments of 5 or 10 kDa molecular weight. A chemotherapeutic drug DOX, was further encapsulated in the interior of these polymer micelles and was shown to exhibit a controlled release profile. Dynamic light scattering and transmission electron microscopy analysis confirmed that the NPs were uniformly sized with a mean hydrodynamic diameter around 110 nm. DOX-loaded H30-PEG10k NPs exhibited controlled release over longer periods of time and greater cytotoxicity compared with the other materials developed against our tested breast cancer cell lines. Additionally, flow cytometry and confocal scanning laser microscopy studies indicated that the cancer cells could internalize the DOX-loaded H30-PEG10k NPs, which contributed to the sustained drug release, and induced more apoptosis than free DOX did. These findings indicate that the H30-PEG10k NPs may offer a very promising approach for delivering drugs to cancer cells. (C) 2011 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 50: 280-288, 2012

Place, publisher, year, edition, pages
Wiley-Blackwell, 2012. Vol. 50, no 2, 280-288 p.
Keyword [en]
biocompatibility, drug delivery systems, hyperbranched
National Category
Polymer Chemistry
URN: urn:nbn:se:kth:diva-70024DOI: 10.1002/pola.25027ISI: 000298479300009ScopusID: 2-s2.0-83455195137OAI: diva2:485774
QC 20120130Available from: 2012-01-30 Created: 2012-01-30 Last updated: 2012-01-30Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textScopus

Search in DiVA

By author/editor
Lundberg, PontusMalkoch, Michael
By organisation
Fibre and Polymer Technology
In the same journal
Journal of Polymer Science Part A: Polymer Chemistry
Polymer Chemistry

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 85 hits
ReferencesLink to record
Permanent link

Direct link