Respiratory syncytial virus protein g expressed on bacterial membrane
1994 (English)Patent (Other (popular science, discussion, etc.))
A method for preparing a peptide or protein, wherein (a) a DNA sequence coding for a heterologous polypeptide on a peptide sequence between amino acid residues 130 and 230 of respiratory syncytial virus protein G, sub-groups A and B, or a peptide sequence at least 80 % homologous thereto, and (b) means enabling the expression of the polypeptide on the bacterial membrane surface, are inserted into a bacterium which is not pathogenic for mammals. The resulting conjugate polypeptide and a live bacterium expressing same, pharmaceutical compositions containing them and their use for preparing a vaccine, as well as a DNA sequence coding for said polypeptide, are also disclosed.
Place, publisher, year, edition, pages
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:kth:diva-70227OAI: oai:DiVA.org:kth-70227DiVA: diva2:486093
FR 2726577B1 (1997-01-31)
AU 704703-B2 (1999-04-29); US 6130091 A (2000-10-10)2012-01-302012-01-302015-01-28Bibliographically approved