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Respiratory syncytial virus protein g expressed on bacterial membrane
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1994 (English)Patent (Other (popular science, discussion, etc.))
Abstract [en]

A method for preparing a peptide or protein, wherein (a) a DNA sequence coding for a heterologous polypeptide on a peptide sequence between amino acid residues 130 and 230 of respiratory syncytial virus protein G, sub-groups A and B, or a peptide sequence at least 80 % homologous thereto, and (b) means enabling the expression of the polypeptide on the bacterial membrane surface, are inserted into a bacterium which is not pathogenic for mammals. The resulting conjugate polypeptide and a live bacterium expressing same, pharmaceutical compositions containing them and their use for preparing a vaccine, as well as a DNA sequence coding for said polypeptide, are also disclosed.

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Medical and Health Sciences
URN: urn:nbn:se:kth:diva-70227OAI: diva2:486093
FR 2726577B1 (1997-01-31)

AU 704703-B2 (1999-04-29); US 6130091 A (2000-10-10)

Available from: 2012-01-30 Created: 2012-01-30 Last updated: 2015-01-28Bibliographically approved

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Ståhl, StefanUhlén, MathiasNygren, Per-Åke
Medical and Health Sciences

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