Sustained Release of Ibuprofen from Polyelectrolyte Encapsulated Mesoporous Carriers
2009 (English)In: Journal of Dispersion Science and Technology, ISSN 0193-2691, E-ISSN 1532-2351, Vol. 30, no 6, 892-902 p.Article in journal (Refereed) Published
Polyelectrolyte multilayers are receiving much attention due to their insoly. and due to structural responses induced in them by changes in soln. properties such as, for example, temp., pH or ionic strength. These characteristics make polyelectrolyte multilayers highly interesting in encapsulation technol. and controlled delivery applications. However, producing dry, biocompatible formulations for storage of low mol. wt. substances poses a challenge. One possibility is to make use of a well-defined mesoporous inorg. carrier material as host for the model substance (in the authors' case ibuprofen). Control over release properties are enabled by polyelectrolyte encapsulation of the inorg. carrier. The authors built such multilayers through consecutive deposition of PAH and PSS on top of a first layer of PEI. These layers were adsorbed either in presence or absent of ibuprofen. The influence of long time storage, 2 years, of the samples was also investigated. The polyelectrolyte multilayer structure was investigated in detail by Dual Polarization Interferometry (DPI), and the authors use these data to interpret the measured release profiles.
Place, publisher, year, edition, pages
Taylor & Francis, 2009. Vol. 30, no 6, 892-902 p.
Dual polarization interferometry (DPI); ibuprofen; mesoporous particles; polyelectrolyte encapsulation; release properties
Other Chemistry Topics
IdentifiersURN: urn:nbn:se:kth:diva-70229DOI: 10.1080/01932690802644095ISI: 000266436200019ScopusID: 2-s2.0-70449337774OAI: oai:DiVA.org:kth-70229DiVA: diva2:486105
QC 201202072012-02-072012-01-302012-03-12Bibliographically approved