Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Sustained Release of Ibuprofen from Polyelectrolyte Encapsulated Mesoporous Carriers
YKI, Institute for Surface Chemistry.
KTH, School of Chemical Science and Engineering (CHE), Chemistry, Surface and Corrosion Science.
KTH, School of Chemical Science and Engineering (CHE), Chemistry, Surface and Corrosion Science.
YKI, Institute for Surface Chemistry.
2009 (English)In: Journal of Dispersion Science and Technology, ISSN 0193-2691, E-ISSN 1532-2351, Vol. 30, no 6, 892-902 p.Article in journal (Refereed) Published
Abstract [en]

Polyelectrolyte multilayers are receiving much attention due to their insoly. and due to structural responses induced in them by changes in soln. properties such as, for example, temp., pH or ionic strength.  These characteristics make polyelectrolyte multilayers highly interesting in encapsulation technol. and controlled delivery applications.  However, producing dry, biocompatible formulations for storage of low mol. wt. substances poses a challenge.  One possibility is to make use of a well-defined mesoporous inorg. carrier material as host for the model substance (in the authors' case ibuprofen).  Control over release properties are enabled by polyelectrolyte encapsulation of the inorg. carrier.  The authors built such multilayers through consecutive deposition of PAH and PSS on top of a first layer of PEI.  These layers were adsorbed either in presence or absent of ibuprofen.  The influence of long time storage, 2 years, of the samples was also investigated.  The polyelectrolyte multilayer structure was investigated in detail by Dual Polarization Interferometry (DPI), and the authors use these data to interpret the measured release profiles.

Place, publisher, year, edition, pages
Taylor & Francis, 2009. Vol. 30, no 6, 892-902 p.
Keyword [en]
Dual polarization interferometry (DPI); ibuprofen; mesoporous particles; polyelectrolyte encapsulation; release properties
National Category
Other Chemistry Topics
Identifiers
URN: urn:nbn:se:kth:diva-70229DOI: 10.1080/01932690802644095ISI: 000266436200019Scopus ID: 2-s2.0-70449337774OAI: oai:DiVA.org:kth-70229DiVA: diva2:486105
Note
QC 20120207Available from: 2012-02-07 Created: 2012-01-30 Last updated: 2017-12-08Bibliographically approved
In thesis
1. Mesostructured particulate silica materials with tunable pore size: Synthesis, characterization and applications
Open this publication in new window or tab >>Mesostructured particulate silica materials with tunable pore size: Synthesis, characterization and applications
2009 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Colloidal assemblies of surfactants and polymers in aqueous solutions have been used by human mankind for hundreds of years and they are of great importance in many of our technological processes, such as fabrication of soap and papermaking. Less than two decades ago the idea of using colloidal assemblies as templates of inorganic materials was borne. A new population of materials, referred to as surfactant templated materials, took form. These materials showed extraordinary properties such as monodisperse pore size distribution, large surface areas and pore volumes.

 

The main focus of this thesis has been on synthesis and functionalisation of spherical mesostructured silica particulate materials. In the first part of the work, mesostructured materials with expanded pores have been produced using a well established aerosol-based method as well as the newly developed emulsion and solvent evaporation (ESE) method. Increase in pore size was realized through using Pluronic block copolymer F127 together with a swelling agent poly(propylene glycol) as template. The influence of the swelling agent on pore size expansion was shown to have a roughly linear relationship. Furthermore, the impact of synthesis parameters on internal and exterior morphology has been investigated. Accessibility of the internal pore space, as well as the external surface roughness were shown to be highly dependent on synthesis temperature. Additionally, a very interesting well ordered 3D closed packed (P63/mmc) material was produced using the ionic surfactant C16TAB as template in the ESE method.

 

In the second part of the thesis work, mesoporous spheres with large pore size, having either hydrophilic or hydrophobic surface properties, were used as carriers of an enzyme, lipase. The enzymatic activity of lipase was increased onto the hydrophobic surface, compared to lipase immobilized into the hydrophilic support as well as for lipase free in solution. This effect was probably due to a combination of enhanced hydrophobic interactions preventing denaturation of the enzyme and interfacial activation of the enzyme.  This study generated an inorganic carrier material that is a promising candidate for biocatalysis applications. Additionally, mesoporous spheres were used as carriers of a model drug, Ibuprofen, to study the effect of polyelectrolyte multilayers on release properties. However, these layers were shown impermeable independent on pH and the substance was only released from uncoated particles.

Place, publisher, year, edition, pages
Stockholm: KTH, 2009. 70 p.
Series
TRITA-CHE-Report, ISSN 1654-1081 ; 2009:8
Keyword
Mesoporous materials, aersol-based process, emulsion-based process, biocatalysis, sustained release, 3D hexagonal, 2D hexagonal, powder, spherical particles, liquid crystalline phases, AFM-porosimetry, Pluronic
National Category
Other Basic Medicine
Identifiers
urn:nbn:se:kth:diva-10089 (URN)978-91-7415-243-2 (ISBN)
Public defence
2009-04-03, E2, Lindstedsvägen 3, Stockholm, 10:00 (English)
Opponent
Supervisors
Note

QC 20100811

Available from: 2009-03-19 Created: 2009-03-11 Last updated: 2014-11-03Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textScopusPublisher's website

Search in DiVA

By author/editor
Samoshina, YuliaPer, Claesson
By organisation
Surface and Corrosion Science
In the same journal
Journal of Dispersion Science and Technology
Other Chemistry Topics

Search outside of DiVA

GoogleGoogle Scholar

doi
urn-nbn

Altmetric score

doi
urn-nbn
Total: 75 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf