655-ORGN - Synthesis of highly enantioenriched cyanohydrins by dual Lewis acid - Lewis base activation
2007 (English)In: Abstract of Papers of the American Chemical Society, ISSN 0065-7727, Vol. 234, 655-ORGN- p.Article in journal (Other academic) Published
Enantioenriched acylated cyanohydrins serve as versatile synthons and are themselves important synthetic targets. By using our efficient catalytic dual Lewis acid - Lewis base activation system, a range of α-ketonitriles were added to both arom. and aliph. aldehydes affording highly enantioenriched O-acylated cyanohydrins in excellent yields. The reactions proceeded smoothly in only one step with perfect atom economy. Our recent results as well as the scope and limitations of the system will be presented together with mechanistic aspects.
Place, publisher, year, edition, pages
2007. Vol. 234, 655-ORGN- p.
IdentifiersURN: urn:nbn:se:kth:diva-71041ISI: 000207594300181OAI: oai:DiVA.org:kth-71041DiVA: diva2:486450
234th ACS National Meeting, Boston, MA
QC 201201312012-01-302012-01-302012-01-31Bibliographically approved