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Nora virus, a persistent virus in Drosophila, defines a new picorna-like virus family
UCMP, Umeå University.
Stockholm University.
UCMP, Umeå University.
2006 (English)In: Journal of General Virology, ISSN 0022-1317, E-ISSN 1465-2099, Vol. 87, no 10, 3045-3051 p.Article in journal (Refereed) Published
Abstract [en]

Several viruses, including picomaviruses, are known to establish persistent infections, but the mechanisms involved are poorly understood. Here, a novel picoma-like virus, Nora virus, which causes a persistent infection in Drosophila melanogaster, is described. It has a sing le-stranded, positive-sense genomic RNA of 11879 nt, followed by a poly(A) tail. Unlike other picoma-like viruses, the genome has four open reading frames (ORFs). One ORF encodes a picornavirus-like cassette of proteins for virus replication, including an iflavirus-like RNA-dependent RNA polymerase and a helicase that is related to those of mammalian picornaviruses. The three other ORFs are not closely related to any previously described viral sequences. The unusual sequence and genome organization in Nora virus suggest that it belongs to a new family of picorna-like viruses. Surprisingly, Nora virus could be detected in all tested D. melanogaster laboratory stocks, as well as in wild-caught material. The viral titres varied enormously, between 10(4) and 10(10) viral genomes per fly in different stocks, without causing obvious pathological effects. The virus was also found in Drosophila simulans, a close relative of D. melanogaster, but not in more distantly related Drosophila species. It will now be possible to use Drosophila genetics to study the factors that control this persistent infection.

Place, publisher, year, edition, pages
2006. Vol. 87, no 10, 3045-3051 p.
National Category
Biochemistry and Molecular Biology
URN: urn:nbn:se:kth:diva-71896DOI: 10.1099/vir.0.81997-0ISI: 000241210400031OAI: diva2:487077
QC 20120201Available from: 2012-01-31 Created: 2012-01-31 Last updated: 2012-02-01Bibliographically approved

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Ekengren, Sophia K.
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