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An analog front-end enables electrical impedance spectroscopy system on-chip for biomedical applications
KTH, School of Technology and Health (STH), Medical sensors, signals and systems (MSSS).ORCID iD: 0000-0002-6995-967X
KTH, School of Technology and Health (STH), Medical sensors, signals and systems (MSSS).
Technical University of Catalonia. (Department of Electronic Engineering)
2008 (English)In: Physiological Measurement, ISSN 0967-3334, E-ISSN 1361-6579, Vol. 29, no 6, S267-78 p.Article in journal (Refereed) Published
Abstract [en]

The increasing number of applications of electrical bioimpedance measurements in biomedical practice, together with continuous advances in textile technology, has encouraged several researchers to make the first attempts to develop portable, even wearable, electrical bioimpedance measurement systems. The main target of these systems is personal and home monitoring. Analog Devices has made available AD5933, a new system-on-chip fully integrated electrical impedance spectrometer, which might allow the implementation of minimum-size instrumentation for electrical bioimpedance measurements. However, AD5933 as such is not suitable for most applications of electrical bioimpedance. In this work, we present a relatively simple analog front-end that adapts AD5933 to a four-electrode strategy, allowing its use in biomedical applications for the first time. The resulting impedance measurements exhibit a very good performance in aspects like load dynamic range and accuracy. This type of minimum-size, system-on-chip-based bioimpedance measurement system would lead researchers to develop and implement light and wearable electrical bioimpedance systems for home and personal health monitoring applications, a new and huge niche for medical technology development.

Place, publisher, year, edition, pages
Institute of Physics Publishing (IOPP), 2008. Vol. 29, no 6, S267-78 p.
Keyword [en]
electrical bioimpedance spectroscopy; system-on-chip; four-electrode method
National Category
Medical Laboratory and Measurements Technologies
Identifiers
URN: urn:nbn:se:kth:diva-73057DOI: 10.1088/0967-3334/29/6/S23ISI: 000257167200024PubMedID: 18544823OAI: oai:DiVA.org:kth-73057DiVA: diva2:488598
Note
QC 20120208Available from: 2012-02-08 Created: 2012-02-01 Last updated: 2017-12-08Bibliographically approved
In thesis
1. Textile-enabled Bioimpedance Instrumentation for Personalised Health Monitoring Applications
Open this publication in new window or tab >>Textile-enabled Bioimpedance Instrumentation for Personalised Health Monitoring Applications
2013 (English)Licentiate thesis, comprehensive summary (Other academic)
Abstract [en]

A growing number of factors, including the costs, technological advancements, an ageing population, and medical errors are leading industrialised countries to invest in research on alternative solutions to improving their health care systems and increasing patients’ life quality. Personal Health System (PHS) solutions envision the use of information and communication technologies that enable a paradigm shift from the traditional hospital-centred healthcare delivery model toward a preventive and person-centred approach. PHS offers the means to follow patient health using wearable, portable or implantable systems that offer ubiquitous, unobtrusive bio-data acquisition, allowing remote access to patient status and treatment monitoring.

Electrical Bioimpedance (EBI) technology is a non-invasive, quick and relatively affordable technique that can be used for assessing and monitoring different health conditions, e.g., body composition assessments for nutrition. EBI technology combined with state-of-the-art advances in sensor and textile technology are fostering the implementation of wearable bioimpedance monitors that use functional garments for the implementation of personalised healthcare applications.

This research studies the development of a portable EBI spectrometer that can use dry textile electrodes for the assessment of body composition for the purposes of clinical uses. The portable bioimpedance monitor has been developed using the latest advances in system-on-chip technology for bioimpedance spectroscopy instrumentation. The obtained portable spectrometer has been validated against commercial spectrometer that performs total body composition assessment using functional textrode garments.

The development of a portable Bioimpedance spectrometer using functional garments and dry textile electrodes for body composition assessment has been shown to be a feasible option. The availability of such measurement systems bring closer the real implementation of personalised healthcare systems.

Place, publisher, year, edition, pages
Stockholm: KTH Royal Institute of Technology, 2013. xvii, 48 p.
Series
Trita-STH : report, ISSN 1653-3836 ; 2013:1
Keyword
personal healthcare systems, bioimpedance, wearable, portable, monitoring, textrodes, body composition, chronic kidney disease, ambient assisting living, wireless sensor
National Category
Medical Engineering Electrical Engineering, Electronic Engineering, Information Engineering
Identifiers
urn:nbn:se:kth:diva-120373 (URN)978-91-7501-702-0 (ISBN)
Presentation
2013-04-29, A608, University of Borås, Borås, 10:00 (English)
Opponent
Supervisors
Note

QC 20130405

Available from: 2013-04-05 Created: 2013-04-04 Last updated: 2013-04-05Bibliographically approved
2. Modular textile-enabled bioimpedance system for personalized health monitoring applications
Open this publication in new window or tab >>Modular textile-enabled bioimpedance system for personalized health monitoring applications
2017 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

A growing number of factors, including costs, technological advancements, ageing populations, and medical errors, are leading industrialized countries to invest in research on alternative solutions to improve their health-care systems and increase patients’ quality of life. Personal health systems (PHS) examplify the use of information and communication technologies that enable a paradigm shift from the traditional hospital-centered healthcare delivery model toward a preventive and person-centered approach. PHS offer the means to monitor a patient’s health using wearable, portable or implantable systems that offer ubiquitous, unobtrusive biodata

acquisition, allowing remote monitoring of treatment and access to the patient’s status. Electrical bioimpedance (EBI) technology is non-invasive, quick and relatively affordable technique that can be used for assessing and monitoring different health conditions, e.g., body composition assessments for nutrition. When combined with state-of-the-art advances in sensors and textiles, EBI technologies are fostering the implementation of wearable bioimpedance monitors that use functional garments for personalized healthcare applications. This research work is

focused on the development of wearable EBI-based monitoring systems for ubiquitous health monitoring applications. The monitoring systems are built upon portable monitoring instrumentation and custom-made textile electrode garments.

Portable EBI-based monitors have been developed using the latest material technology and advances in system-on-chip technology. For instance, a portable EBI spectrometer has been validated against a commercial spectrometer for total body composition assessment using functional textile electrode garments. The development of wearable EBI-based monitoring units using functional garments and dry textile electrodes for body composition assessment and respiratory monitoring has been shown to be a feasible approach. The availability of these measurement systems indicates progress toward the real implementation of personalized healthcare systems.

Place, publisher, year, edition, pages
Stockholm: KTH Royal Institute of Technology, 2017. 89 p.
Series
TRITA-STH, 2017:6
Keyword
personal healthcare system, electrical bioimpedance, wearable sensors, pervasive monitoring, portable monitoring, body composition, chronic kidney disease, wireless sensor, ubiquitous, instrumentation
National Category
Medical Laboratory and Measurements Technologies
Research subject
Technology and Health
Identifiers
urn:nbn:se:kth:diva-207135 (URN)978-91-7729-377-4 (ISBN)
Public defence
2017-06-02, M402, Allégatan 1, Borås, 10:00 (English)
Opponent
Supervisors
Note

QC 20170517

Available from: 2017-05-17 Created: 2017-05-17 Last updated: 2017-05-17Bibliographically approved

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Seoane, Fernando

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