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Bioelectrical Impedance During Hypoxic Cell Swelling: Modeling of Tissue as a Suspension of Cells
School of Engineering, University College of Borås, SE-50190 Borås.ORCID iD: 0000-0002-6995-967X
School of Engineering, University College of Borås, SE-50190 Borås.
bDepartment of Signal and Systems, Chalmers University of Technology, SE-41296 Gothenburg.
cDepartment of Pediatrics, Göteborg University, The Queen Silvia Children's Hospital, SE-41685 Gothenburg.
2004 (English)Conference paper (Refereed)
Abstract [en]

Non-invasive multi-frequency measurements of transcephalic impedance, both reactance and resistance, can efficiently detect cytotoxic edema in brain tissue and can be used for early detection of threatening brain damage. The model of biological tissue as a suspension of cells can be used as a valuable guide to identify the optimum range of frequencies for electrical impedance monitoring to detect cell swelling efficiently. We have performed experiments on piglets to monitor transcephalic impedance during hypoxia. The obtained results have confirmed the hypothesis that changes in the size of cells modify the tissue impedance. During tissue inflammation after induced hypoxia, cerebral tissue exhibits changes in both reactance and resistance. Those changes in impedance exhibit certain dependency of frequency in concordance with the suspension of cells model. The experimentally observed changes are remarkably high, up to 71% over the baseline, and easy to measure especially at certain frequencies. A better understanding of the electrical behaviour of cerebral tissue during cell swelling may lead the development effective non-invasive clinical tools and methods for early diagnosis of cerebral edema and brain damage prevention.

Place, publisher, year, edition, pages
Gdansk, 2004. 73-76 p.
Keyword [en]
Bio-impedance, Brain Damage, Cell Swelling, Cerebral Edema, Cole Plot, Hypoxia, Ischemia, Suspension of Cells, Tissue inflammation
National Category
Medical Laboratory and Measurements Technologies Other Electrical Engineering, Electronic Engineering, Information Engineering
URN: urn:nbn:se:kth:diva-73195ISBN: 83-917681-6-3OAI: diva2:488629
XII International Conference on Electrical Bioimpedance & V Electrical Impedance Tomography
QC 20120206Available from: 2012-02-06 Created: 2012-02-01 Last updated: 2012-02-17Bibliographically approved
In thesis
1. Electrical Bioimpedance Cerebral Monitoring: Effects of Hypoxia
Open this publication in new window or tab >>Electrical Bioimpedance Cerebral Monitoring: Effects of Hypoxia
2005 (English)Licentiate thesis, comprehensive summary (Other academic)
Abstract [en]

Electrical bioimpedance spectroscopy is one way to study the electrical properties of biological matter. Different applications of electrical bioimpedance measurements have already been used in both research and clinical scenarios i.e. impedance plethysmography, total body water contents, etc. The electrical properties of tissue reflect the electrical characteristics of the constituent elements of the tissue and depend on its structure. Thus study of the electrical properties not only makes it possible to differentiate among tissues but also to determine the tissue condition. During hypoxia/ischemia the cell activates a certain chain of mechanisms of cellular adaptation in response to the insult. A consequence of these response mechanisms is that the biochemical composition of the cellular environment is altered and the cells swell (cellular edema). These alterations affect the electrical properties of tissue and the changes can be observed through measurement of the electrical bioimpedance of the affected tissue. Based on these ideas, this research work studies the effects of hypoxia/ischemia on the brain electrical impedance. The aim is to obtain the fundamental knowledge that may lead to the development of useful clinical tools for cerebral monitoring based on electrical bioimpedance spectroscopy. 

Place, publisher, year, edition, pages
Gothenburg: Chalmers Reproservice, 2005. 84 p.
, Chalmers Technical Reports, ISSN 1403-266X ; R012/2005
National Category
Medical Laboratory and Measurements Technologies
urn:nbn:se:kth:diva-80373 (URN)
2015-04-17, EA4, Gothenburg, 13:00 (English)
Brain damage, Detection and localization of cell swelling
QC 20120217Available from: 2012-02-17 Created: 2012-02-09 Last updated: 2012-02-17Bibliographically approved

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