Bioelectrical Impedance During Hypoxic Cell Swelling: Modeling of Tissue as a Suspension of Cells
2004 (English)Conference paper (Refereed)
Non-invasive multi-frequency measurements of transcephalic impedance, both reactance and resistance, can efficiently detect cytotoxic edema in brain tissue and can be used for early detection of threatening brain damage. The model of biological tissue as a suspension of cells can be used as a valuable guide to identify the optimum range of frequencies for electrical impedance monitoring to detect cell swelling efficiently. We have performed experiments on piglets to monitor transcephalic impedance during hypoxia. The obtained results have confirmed the hypothesis that changes in the size of cells modify the tissue impedance. During tissue inflammation after induced hypoxia, cerebral tissue exhibits changes in both reactance and resistance. Those changes in impedance exhibit certain dependency of frequency in concordance with the suspension of cells model. The experimentally observed changes are remarkably high, up to 71% over the baseline, and easy to measure especially at certain frequencies. A better understanding of the electrical behaviour of cerebral tissue during cell swelling may lead the development effective non-invasive clinical tools and methods for early diagnosis of cerebral edema and brain damage prevention.
Place, publisher, year, edition, pages
Gdansk, 2004. 73-76 p.
Bio-impedance, Brain Damage, Cell Swelling, Cerebral Edema, Cole Plot, Hypoxia, Ischemia, Suspension of Cells, Tissue inflammation
Medical Laboratory and Measurements Technologies Other Electrical Engineering, Electronic Engineering, Information Engineering
IdentifiersURN: urn:nbn:se:kth:diva-73195ISBN: 83-917681-6-3OAI: oai:DiVA.org:kth-73195DiVA: diva2:488629
XII International Conference on Electrical Bioimpedance & V Electrical Impedance Tomography
QC 201202062012-02-062012-02-012012-02-17Bibliographically approved