Alcohols as enantioselective inhibitors in a lipase catalysed esterification of a chiral acyl donor
1995 (English)In: Biotechnology Letters, ISSN 01415492 (ISSN), Vol. 17, no 1, 55-60 p.Article in journal (Refereed) Published
Increased reaction rates and increased enantioselectivities were observed with decreased concentrations of n-alkanols when resolving 2-methyldecanoic acid by esterification catalysed by immobilised lipase from Candida rugosa at controlled water activities in cyclohexane. The enantioselectivity was found to be independent of the water activity in the reaction medium at the n-heptanol concentrations investigated. However, when n-decanol was used as the acyl acceptor, not only the alcohol concentration but also the water activity in the reaction medium, influenced the enantioselectivity. The results obtained showed that the low enantioselectivity seen at a high alcohol concentration could be explained by the alcohol influencing the apparent V(max)(S) and V(max)(R) differently.
Place, publisher, year, edition, pages
1995. Vol. 17, no 1, 55-60 p.
alcohol derivative, cyclohexane, decanoic acid derivative, triacylglycerol lipase, article, candida, catalysis, chemical reaction kinetics, chemical structure, concentration (parameters), enantiomer, esterification, nonhuman, Candida rugosa
IdentifiersURN: urn:nbn:se:kth:diva-74872DOI: 10.1007/BF00134196OAI: oai:DiVA.org:kth-74872DiVA: diva2:490137
Correspondence Address: Berglund, P.; Department Science and Engineering, Mid Sweden University, S-851 70 Sundsvall, Sweden NR 201408052012-02-032012-02-032012-02-03Bibliographically approved