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Resolution of 2-methylalkanoic acids. Enantioselective esterification with long chain alcohols catalysed by Candida rugosa lipase
Mid Sweden University.ORCID iD: 0000-0002-9577-832X
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1996 (English)In: Acta Chemica Scandinavica, ISSN 0904213X (ISSN), Vol. 50, no 8, 666-671 p.Article in journal (Refereed) Published
Abstract [en]

Candida rugosa lipase catalysed resolutions of 2-methylalkanoic acids run on a large scale often display decreased enantiomeric rations (E-values) and reaction rates compared with small-scale experiments. By continuous control of the water activity (addition of inorganic salt/hydrated salt mixtures) this can be avoided. The importance of the proper choice of alcohol as well as its concentration is demonstrated. (R)-2-Methyloctanoic acid (8.6g) and (S)-2-methyl-1-octanol (4.5 g), both in 99.6% ee were prepared from 20 g racemic 2-methyloctanoic acid. © Acta Chemica Scandinavica 1996.

Place, publisher, year, edition, pages
1996. Vol. 50, no 8, 666-671 p.
National Category
Organic Chemistry
URN: urn:nbn:se:kth:diva-74871OAI: diva2:490140
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