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Visual evoked potentials in disproportionately growth-retarded human neonates
Department of Clinical Neurophysiology, Institute of Neuroscience and Physiology, Sahlgrenska University Hospital, Göteborg, Sweden.
Department of Signals and Systems, Chalmers.
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2004 (English)In: Pediatric Neurology, ISSN 0887-8994, E-ISSN 1873-5150, Vol. 30, no 4, 262-270 p.Article in journal (Refereed) Published
Abstract [en]

To study brain function in the neonatal period, disproportionately growth-retarded (n = 33) and appropriately grown (n = 21) infants were examined using Doppler flow velocities prenatally and visual evoked potentials postnatally. Visual evoked potentials recordings were made at gestation of 40 and 46 weeks. The group of growth-retarded infants had significantly prolonged latencies to both of the two major peaks (designated P and N), most pronounced for the P peak. This result was observed at both ages investigated and corresponds to a developmental delay of 3 weeks. For individuals, the increase in P latency correlated to prenatal flow indices and to neonatal anthropometric parameters indicative of growth retardation. We conclude that in utero growth retardation affects brain development as assessed by visual evoked potentials in the neonatal period. This developmental delay may be produced by intracerebral factors during the process of growth retardation, and these alterations may have a prognostic value.

Place, publisher, year, edition, pages
2004. Vol. 30, no 4, 262-270 p.
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URN: urn:nbn:se:kth:diva-75353DOI: 10.1016/j.pediatrneurol.2003.10.002ISI: 000221138700007PubMedID: 15087105OAI: diva2:491059
QC 20120206Available from: 2012-02-06 Created: 2012-02-05 Last updated: 2012-02-06Bibliographically approved

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