Ion conducting polymer microelectrodes for interfacing with neural networks
2007 (English)In: Journal of Neuroscience Methods, ISSN 0165-0270, E-ISSN 1872-678X, Vol. 160, no 1, 16-25 p.Article in journal (Refereed) Published
We have examined the stimulation and recording properties of conjugated polymer microelectrode arrays as interfaces with neural networks of dissociated cortical cells. In particular the stimulation properties were investigated as a means of supplying a neural network with information. The stimulation efficiency at low stimulation voltages was evaluated and referenced to bare indium tin oxide (ITO) electrodes. The polymer electrodes were electrochemically polymerized from a blend of poly(3,4-ethylenedioxythiophene)-poly(styrenesulfonate) (PEDOT-PSS) and ethylenedioxythiophene (EDOT) onto ITO microelectrodes. Dissociated cortical cells were then plated on the electrodes and cultivated to form neural networks. Polymer electrode stimulation evoked a much greater response from the network than stimulation from ITO electrodes. Neural interfaces using polymer electrodes could be maintained for several months.
Place, publisher, year, edition, pages
2007. Vol. 160, no 1, 16-25 p.
Electrical stimulation, Neural network, Microelectrode array, MEA, Conducting polymer, PEDOT-PSS
Biomaterials Science Neurosciences Medical Materials Polymer Chemistry
IdentifiersURN: urn:nbn:se:kth:diva-77489DOI: 10.1016/j.jneumeth.2006.08.008ISI: 000244241700004PubMedID: 17000006OAI: oai:DiVA.org:kth-77489DiVA: diva2:491739
QC 201202172012-02-072012-02-072012-02-17Bibliographically approved