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Heart rate variability (HRV) in adolescent females with anxiety disorders and major depressive disorder
KTH, School of Technology and Health (STH), Ergonomics (Closed 20130701). (Ergonomi)
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2010 (English)In: Acta Paediatrica, ISSN 0803-5253, E-ISSN 1651-2227, Vol. 99, no 4, 604-611 p.Article in journal (Refereed) Published
Abstract [en]

AIM: The aim of this study was to investigate heart rate variability (HRV) in a clinical sample of female adolescents with anxiety disorders (AD) and/or major depressive disorder (MDD) compared with healthy controls and to assess the effect of selective serotonin reuptake inhibitors (SSRI) on HRV.

METHODS: Heart rate variability was measured in adolescent female psychiatric patients with AD and/or MDD (n = 69), mean age 16.8 years (range: 14.5-18.4), from 13 out-patient clinics and in healthy controls (n = 65), mean age 16.5 years (range: 15.9-17.7). HRV was registered in the sitting position during 4 min with no interventions.

RESULTS: Logarithmically transformed high frequency HRV (HF), low frequency HRV (LF) and standard deviation of inter beat intervals (SDNN) were lower in the clinical sample compared with the controls (Cohen's d for HF = 0.57, LF = 0.55, SDNN = 0.60). This was not explained by body mass index, blood pressure or physical activity. Medication with SSRI explained 15.5% of the total variance of HF, 3.0% of LF and 6.5% of SDNN.

CONCLUSIONS: Adolescent female psychiatric patients with AD and/or MDD show reduced HRV compared with healthy controls. Medication with SSRI explained a part of this difference.

Place, publisher, year, edition, pages
2010. Vol. 99, no 4, 604-611 p.
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Medical and Health Sciences
URN: urn:nbn:se:kth:diva-77534DOI: 10.1111/j.1651-2227.2009.01657.xISI: 000274951200029PubMedID: 20121706ScopusID: 2-s2.0-77649199977OAI: diva2:491825

QC 20120210

Available from: 2012-02-07 Created: 2012-02-07 Last updated: 2016-05-11Bibliographically approved

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Ericson, Mats
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