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Long-term stability of heart rate variability in chronic stable angina pectoris, and the impact of an acute myocardial infarction
Stockholm University College of Physical Education and Sports, Stockholm, Sweden.
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2009 (English)In: Clinical Physiology and Functional Imaging, ISSN 1475-0961, E-ISSN 1475-097X, Vol. 29, no 3, 201-208 p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Heart rate variability (HRV) reflects the balance between cardiac parasympathetic and sympathetic autonomic influences. Reduced HRV has adverse prognostic implications. The time course for changes in HRV over prolonged periods of time and the influence of an acute coronary event on HRV are not well established.

METHODS: Heart rate variability was assessed in patients with chronic stable angina pectoris, who were followed for 3 years within the Angina Prognosis Study in Stockholm. Patients who suffered an acute myocardial infarction after the study were re-examined after this event. We assessed HRV by the simple geometric method differential index, and traditional time- and frequency-domain measurements of HRV.

RESULTS: The differential index was essentially unchanged during the study (i.e. the ratio month 36/month 1 was 1.00 +/- 0.06, n = 261). Also most other time and frequency indices of HRV (SDNN, r-MSSD, SDNNIDX, total power, and VLF, LF, HF respectively; n = 63) remained largely unchanged; pNN50 and LF/HF were, however, less reproducible. In 21 patients with a subsequent acute myocardial infarction, SDNN, SDNNIDX, total power, LF and LF/HF were reduced following the event, whereas differential index, pNN50 and HF remained unchanged.

CONCLUSIONS: Differential index and other indices of HRV are stable and reproducible in patients with chronic stable angina pectoris. High-frequency HRV (reflecting cardiac parasympathetic activity) and the differential index changed little following an acute coronary event, and may be suitable for predictions of the future risk of sudden death even in the presence of a recent acute coronary event.

Place, publisher, year, edition, pages
2009. Vol. 29, no 3, 201-208 p.
Keyword [en]
autonomic nervous system, human, ischaemic heart disease, prognosis
National Category
Medical and Health Sciences
URN: urn:nbn:se:kth:diva-77536DOI: 10.1111/j.1475-097X.2009.00857.xISI: 000264545000008PubMedID: 19254330OAI: diva2:491852
QC 20120217Available from: 2012-02-07 Created: 2012-02-07 Last updated: 2012-02-17Bibliographically approved

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