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Abnormal heart rate response to hypercapnia in boys with an apparent life-threatening event.
KTH, School of Technology and Health (STH), Ergonomics. (Ergonomi)
2002 (English)In: Acta Paediatrica, ISSN 0803-5253, E-ISSN 1651-2227, Vol. 91, no 12, 1318-23 p.Article in journal (Refereed) Published
Abstract [en]

AIM: To determine instantaneous cardiac variability responses to increased carbon dioxide (CO2) during quiet sleep in infants who may be at risk for the Sudden Infant Death syndrome (SIDS).

METHODS: The cardiac rate variability before, during and after a CO2 challenge was examined in 41 infants who had experienced an apparent life-threatening event (ALTE) and 41 gender- and age-matched control infants.

RESULTS: The ALTE infants responded to CO2 breathing with a significant increase in R-R intervals, i.e. decreases in heart rate, compared to the controls (45.1% increase in R-R intervals vs. 41.4%; p = 0.005). The differences between ALTE infants and controls depended primarily on the boys' responses.

CONCLUSION: ALTE infants, particularly ALTE boys, have an autonomic dysfunction-lower sympathetic stimulation and/or inhibited vagal withdrawal when stressed with CO2. The outcome might provide clues to the mechanisms underlying the cardiovascular processes contributing to the terminal event in SIDS.

Place, publisher, year, edition, pages
2002. Vol. 91, no 12, 1318-23 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:kth:diva-77552PubMedID: 12578288OAI: diva2:491875
NR 20140805Available from: 2012-02-07 Created: 2012-02-07 Last updated: 2012-02-12Bibliographically approved

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