Change search
ReferencesLink to record
Permanent link

Direct link
Diminished circadian variation in heart rate variability before surgery in patients developing postoperative atrial fibrillation.
KTH, School of Technology and Health (STH), Ergonomics. (Ergonomi)
Show others and affiliations
2001 (English)In: Scandinavian Cardiovascular Journal, ISSN 1401-7431, Vol. 35, no 4, 238-44 p.Article in journal (Refereed) Published
Abstract [en]

OBJECTIVE: To evaluate the role of the autonomic nervous system for the development of atrial fibrillation (AF) after coronary artery bypass surgery.

DESIGN: Eighty patients without a previous history of AF were included. The sympathetic and parasympathetic activity were evaluated by the analysis of heart rate variability (HRV) in the frequency domain from 24-h Holter recordings and by measuring neuropeptides (neuropeptide Y, chromogranin A, chromogranin B, and pancreatic polypeptide (PP)) and catecholamines, obtained pre- and postoperatively.

RESULTS: Preoperatively, patients (36.3%) developing AF postoperatively showed a statistically significant less circadian variation in the HRV variables, the high-frequency (HF) component (p = 0.013) and the low-frequency (LF)/HF ratio (p = 0.007), than patients remaining in sinus rhythm. The HF component and PP. both reflecting parasympathetic activity, and all other variables in the frequency domain, decreased significantly after surgery in both patient groups (p < 0.0001). Although catecholamines increased significantly postoperatively in both patient groups, neither catecholamines nor neuropeptides expressing sympathetic activity, differed between the two groups. PP was, however, significantly higher in patients with postoperative AF than in those with sinus rhythm postoperatively on day 1.

CONCLUSION: The diminished circadian variation in HRV before surgery and the indirect signs of a higher parasympathetic activity in patients developing postoperative AF compared with patients remaining in sinus rhythm, may indicate a propensity for AF.

Place, publisher, year, edition, pages
2001. Vol. 35, no 4, 238-44 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:kth:diva-77554PubMedID: 11759117OAI: diva2:491999
NR 20140805Available from: 2012-02-07 Created: 2012-02-07 Last updated: 2012-02-12Bibliographically approved

Open Access in DiVA

No full text

By organisation
In the same journal
Scandinavian Cardiovascular Journal
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 21 hits
ReferencesLink to record
Permanent link

Direct link