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Membrane-induced bundling of actin filaments
University of California at Berkeley. (Erik Lindahl)
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2008 (English)In: Nature Physics, ISSN 1745-2473, E-ISSN 1745-2481, Vol. 4, no 10, 789-793 p.Article in journal (Refereed) Published
Abstract [en]

Dynamic interplay between the plasma membrane and underlying cytoskeleton is essential for cellular shape change. Spatial organization of actin filaments, the growth of which generates membrane deformations during motility(1), phagocytosis(2), endocytosis(3) and cytokinesis(4), is mediated by specific protein-protein interactions that branch, crosslink and bundle filaments into networks that interact with the membrane. Although membrane curvature has been found to influence binding of proteins with curvature-sensitive domains(5), the direct e effect of membrane elasticity on cytoskeletal network organization is not clear. Here, we show through in vitro reconstitution and elastic modelling that a lipid bilayer can drive the emergence of bundled actin filament protrusions from branched actin filament networks, thus playing a role normally attributed to actin-binding proteins. Formation of these filopodium-like protrusions with only a minimal set of purified proteins points to an active participation of the membrane in organizing actin filaments at the plasma membrane. In this way, elastic interactions between the membrane and cytoskeleton can cooperate with accessory proteins to drive cellular shape change.

Place, publisher, year, edition, pages
2008. Vol. 4, no 10, 789-793 p.
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URN: urn:nbn:se:kth:diva-79158DOI: 10.1038/nphys1071ISI: 000259686800013OAI: diva2:495178
QC 20120227Available from: 2012-02-08 Created: 2012-02-08 Last updated: 2012-02-27Bibliographically approved

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