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Microscopic implications of S-DNA
Center for Biomembrane Research, Department of Biochemistry and Biophysics, Stockholm University.
2010 (English)In: Physical Review E. Statistical, Nonlinear, and Soft Matter Physics, ISSN 1539-3755, E-ISSN 1550-2376, Vol. 82, no 2Article in journal (Refereed) Published
Abstract [en]

Recent experiments [J. van Mameren et al., Proc. Natl. Acad. Sci. U.S.A. 106, 18231 (2009)] provide a detailed spatial picture of overstretched DNA, showing that under certain conditions the two strands of the double helix separate at about 65 pN. It was proposed that this observation rules out the existence of an elongated, hybridized form of DNA (S-DNA). Here, we argue that the S-DNA picture is consistent with the observation of unpeeling during overstretching. We demonstrate that assuming the existence of S-DNA does not imply DNA overstretching to consist of the complete or near-complete conversion of the molecule from B to S form. Instead, this assumption implies in general a more complex dynamic coexistence of hybridized and unhybridized forms of DNA. We argue that such coexistence can rationalize several recent experimental observations.

Place, publisher, year, edition, pages
2010. Vol. 82, no 2
National Category
Biophysics
Identifiers
URN: urn:nbn:se:kth:diva-79166DOI: 10.1103/PhysRevE.82.021907ISI: 000280757700005OAI: oai:DiVA.org:kth-79166DiVA: diva2:495186
Note
QC 20120209Available from: 2012-02-08 Created: 2012-02-08 Last updated: 2017-12-07Bibliographically approved

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