[Changes in cAMP reception in the cytosol of the developing rat kidney].
1986 (Russian)In: Biokhimii͡a (Moscow, Russia), ISSN 0320-9725, Vol. 51, no 1, 77-9 p.Article in journal (Refereed) Published
The age-dependent changes in the cAMP-binding activity of renal papillary cytosol were studied in intact rats and in animals with experimental delay in development of the concentrating renal function induced by hydrocortisone injection in early postnatal period. The age dynamics of specific cAMP binding in the experimental group differ significantly from that in intact and control (sham injected) animals. It is suggested that the developmental changes in experimental animal kidneys are due to disturbances in hormonal regulation of renal tissue differentiation caused by the changes in intracellular receptors of cAMP. Another possible reason for the observed delay of development of the renal function is the weakening of the stimulating effect of endogenous cAMP on the genome function due to cAMP receptor deficiency in the cell.
Place, publisher, year, edition, pages
1986. Vol. 51, no 1, 77-9 p.
IdentifiersURN: urn:nbn:se:kth:diva-80479PubMedID: 3006801OAI: oai:DiVA.org:kth-80479DiVA: diva2:496354
NR 201408052012-02-092012-02-092012-02-09Bibliographically approved