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[Changes in cAMP reception in the cytosol of the developing rat kidney].
KTH, School of Engineering Sciences (SCI), Applied Physics, Cell Physics.
1986 (Russian)In: Biokhimii͡a (Moscow, Russia), ISSN 0320-9725, Vol. 51, no 1, 77-9 p.Article in journal (Refereed) Published
Abstract [ru]

The age-dependent changes in the cAMP-binding activity of renal papillary cytosol were studied in intact rats and in animals with experimental delay in development of the concentrating renal function induced by hydrocortisone injection in early postnatal period. The age dynamics of specific cAMP binding in the experimental group differ significantly from that in intact and control (sham injected) animals. It is suggested that the developmental changes in experimental animal kidneys are due to disturbances in hormonal regulation of renal tissue differentiation caused by the changes in intracellular receptors of cAMP. Another possible reason for the observed delay of development of the renal function is the weakening of the stimulating effect of endogenous cAMP on the genome function due to cAMP receptor deficiency in the cell.

Place, publisher, year, edition, pages
1986. Vol. 51, no 1, 77-9 p.
National Category
Cell Biology
URN: urn:nbn:se:kth:diva-80479PubMedID: 3006801OAI: diva2:496354
NR 20140805Available from: 2012-02-09 Created: 2012-02-09 Last updated: 2012-02-09Bibliographically approved

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