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Allele-specific primer extension assay
KTH, Superseded Departments, Biotechnology.
KTH, Superseded Departments, Biotechnology.
2001 (English)Patent (Other (popular science, discussion, etc.))
Abstract [en]

The present invention provides methods of allele-specific primer extension useful for detecting mutations and genetic variations. In particular the invention provides a method of detecting a base at a pre-determined position in a nucleic acid molecule, said method comprising: performing primer extension reactions using base-specific detection primers, each primer being specific for a particular base at said predetermined position, and comparing said primer extensions to determine which base is present at said position, wherein said primer extension reactions are performed using labelled nucleotides and wherein a nucleotide-degrading enzyme is present during the primer extension reaction.

Place, publisher, year, edition, pages
Keyword [en]
gene mutation variation technology
National Category
Engineering and Technology
Research subject
SRA - Molecular Bioscience
URN: urn:nbn:se:kth:diva-82375OAI: diva2:498167
WO 2002068684A3

QS 2015

Available from: 2012-02-11 Created: 2012-02-11 Last updated: 2015-01-27Bibliographically approved

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Lundeberg, JoakimNyrén, Pål
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