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HyperSPECT: a new system for pre-clinical imaging in vivo
KTH, School of Engineering Sciences (SCI), Physics, Physics of Medical Imaging.
KTH, School of Engineering Sciences (SCI), Physics, Physics of Medical Imaging.ORCID iD: 0000-0002-7725-0548
KTH, School of Engineering Sciences (SCI), Physics, Physics of Medical Imaging.
KTH, School of Engineering Sciences (SCI), Physics, Physics of Medical Imaging.ORCID iD: 0000-0002-3039-9791
2009 (English)In: Medical Imaging 2009: Physics of Medical Imaging, SPIE - International Society for Optical Engineering, 2009, Vol. 7258, no 1Conference paper, Published paper (Refereed)
Abstract [en]

Imaging in general is becoming increasingly important in the medical science. At the cell level it is possible to label and trace almost individual molecules in vivo to study biochemical reactions using microscopy. In vivo imaging of living organisms is today mainly accomplished by PET, SPECT and fMRI. The problem is that the spatial resolution for realistic image acquisition times is of the order 1-3 mm, which is a serious limitation. We propose a new imaging modality, based on the same principles as SPECT but with drastically improved efficiency and spatial resolution. This is achieved by incorporating a large number of x-ray lenses between the detectors and the object. In current SPECT a pin-hole geometry is standard, involving an unfortunate trade-off between efficiency and spatial resolution, our solution would change this. The agent for radiolabelling is assumed to be 125I, with an emission peak at 27 keV, since it is widely used and easy to handle. The large area, photon counting detectors will consist of a columnar CsI scintillator coupled to a CMOS integrated circuit for electronic read-out. Our simulations of the entire system and of the detector indicate that a resolution of 50 μm for the system is possible.

Place, publisher, year, edition, pages
SPIE - International Society for Optical Engineering, 2009. Vol. 7258, no 1
Series
Progress in Biomedical Optics and Imaging - Proceedings of SPIE, ISSN 1605-7422 ; 7258
Keyword [en]
CMOS, Columnar CsI, Photon-Counting, SPECT
National Category
Atom and Molecular Physics and Optics Medical Equipment Engineering
Identifiers
URN: urn:nbn:se:kth:diva-84825DOI: 10.1117/12.812964Scopus ID: 2-s2.0-66749125464ISBN: 9780819475091 (print)OAI: oai:DiVA.org:kth-84825DiVA: diva2:499666
Conference
Medical Imaging 2009: Physics of Medical Imaging. Lake Buena Vista, FL. 9 February 2009 - 12 February 2009
Note

QC 20120213

Available from: 2012-02-13 Created: 2012-02-13 Last updated: 2017-03-30Bibliographically approved

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Nillius, Peter

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