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Synthesis of Glyconanomaterials via Photo-Initiated Coupling Chemistry
Portland State University, United States .
KTH, School of Chemical Science and Engineering (CHE), Chemistry, Organic Chemistry.
KTH, School of Chemical Science and Engineering (CHE), Chemistry, Organic Chemistry.
KTH, School of Chemical Science and Engineering (CHE), Chemistry, Organic Chemistry.
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2011 (English)In: Petite and sweet: glyco-nanotechnology as a bridge to new medicines, American Chemical Society (ACS), 2011, Vol. 1091, 49-67 p.Conference paper (Refereed)
Abstract [en]

Glyconanomaterials, broadly defined as carbohydrate-presenting structures below 100 nm in size, exhibit remarkable chemical and physical properties with high potential for modern biomedical applications. In this chapter, current synthetic approaches for fabricating glyconanomaterials are summarized, with special emphasis on a novel photocoupling strategy to conjugate carbohydrates onto a wide variety of nanomaterials. Based on the photochemically induced reaction of perfluorophenylazide, different glyconanomaterials were efficiently synthesized, and the resulting structures used in a range of applications. The results demonstrate that this approach to carbohydrate presentation at nanomaterial surfaces leads to efficient and selective binding to cognate proteins, enabling new applications in carbohydrate-lectin recognition, profiling, biosensing, screening, cell imaging, and bacteria detection.

Place, publisher, year, edition, pages
American Chemical Society (ACS), 2011. Vol. 1091, 49-67 p.
, ACS symposium series, ISSN 0097-6156 ; 1091
Keyword [en]
Medical applications, Nanostructured materials, Proteins, Bacteria detection, Biomedical applications, Chemical and physical properties, Coupling chemistry, High potential, New applications, Selective binding, Synthetic approach
National Category
Chemical Sciences
URN: urn:nbn:se:kth:diva-86098DOI: 10.1021/bk-2011-1091.ch004ISI: 000313021800004ScopusID: 2-s2.0-84905578833ISBN: 978-084122688-3OAI: diva2:500404
Symposium on Petite and Sweet: Glyco-Nanotechnology as a Bridge to New Medicines, Aug 22-26, 2010, Boston, United States

QC 20120214

Available from: 2012-02-13 Created: 2012-02-13 Last updated: 2015-04-22Bibliographically approved

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Wang, XinNorberg, OscarDeng, LingquanRamström, OlofYan, Mingdi
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