Perfusion of an IgG producing CHO cell line at very high cell density by ATF or by TFF in WAVE Bioreactor™
2011 (English)Conference paper (Other academic)
Perfusion of an IgG producing CHO cell line was performed in a WAVE Bioreactor™ using either Alternating Tangential Flow or Tangential Flow Filtration. The properties and performances obtained in this bioreactor with both filtration systems were studied.
- Very high cell densities were achieved and could be stably maintained at high viability indicating of a healthy process suitable for instance for efficient cell banking.
Cell density could be significantly further increased showing the capacity of the system set-up.
Place, publisher, year, edition, pages
perfusion, hollow fiber filter, perfusion, ATF, TFF, CHO cells
Research subject SRA - Molecular Bioscience
IdentifiersURN: urn:nbn:se:kth:diva-87442OAI: oai:DiVA.org:kth-87442DiVA: diva2:501653
HansonWade Conference Optimizing Cell Line Performance, July, 26-28, 2011, London, UK
Invited speaker at the Hanson Wade Conference Optimizing Cell Line Performance, July, 26-28, 2011, London, UK. QC 201303192012-02-142012-02-142012-03-19Bibliographically approved