Two-fraction and three-fraction continuous simulated moving bed separation of nucleosides
2004 (English)In: Journal of Chromatography A, ISSN 0021-9673, E-ISSN 1873-3778, Vol. 1043, no 2, 201-210 p.Article in journal (Refereed) Published
A new experimental set-up and a new simulated moving bed (SMB) operation are presented in this work. A desktop SMB unit developed as a modification of the commercial AKTA(TM) explorer working platform has been utilized for the separation of different mixtures of nucleosides. Both two fraction and three fraction SMB separations have been carried out, the latter made possible by the adoption of a new SMB configuration and operating mode (three fraction SMB, 3F-SMB, operation). Experiments demonstrate the feasibility of the 3F-SMB operation, and confirm the trends predicted based on considerations about retention of the components to be separated along the unit.
Place, publisher, year, edition, pages
2004. Vol. 1043, no 2, 201-210 p.
simulated moving bed, preparative chromatography, nucleosides
Chemical Process Engineering Pharmaceutical Chemistry
IdentifiersURN: urn:nbn:se:kth:diva-87900DOI: 10.1016/j.chroma.2004.05.094ISI: 000222807500009OAI: oai:DiVA.org:kth-87900DiVA: diva2:502003
QC 201202292012-02-142012-02-142012-02-29Bibliographically approved