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Phase Diagram of a Chiral Substance Exhibiting Oiling Out in Cyclohexane
Institute of Process Engineering, ETH Zurich.ORCID iD: 0000-0001-7995-3151
2010 (English)In: Crystal Growth & Design, ISSN 1528-7483, E-ISSN 1528-7505, Vol. 10, no 9, 4005-4013 p.Article in journal (Refereed) Published
Abstract [en]

This work investigates the ternary phase diagram of the enantiomers of ethyl-2-ethoxy-3-(4-hydroxyphenyl)propanoate (EEHP) in cyclohexane. The enantiomers of EEHP form aconglomerate, and both the pure enantiomer and the racemic mixture exhibit stable oilingout in cyclohexane. Our analysis shows that the ternary phase diagram of such a system assumes a unique structural evolution around the onset temperature of oiling out; that is, we found that the onset of oiling out strictly occurs through the emergence of a second liquid phase of racemic composition. Furthermore, we found that the further evolution of the ternary phase diagram, i.e., above the onset temperature of oiling out, is dictated by the properties of the phase diagrams pure enantiomer/solvent and racemic mixture/solvent. Our theoretical considerations are in excellent agreement with experimental measurements of EEHP in cyclohexane. 

Place, publisher, year, edition, pages
2010. Vol. 10, no 9, 4005-4013 p.
Keyword [en]
Experimental measurements, Liquid Phase, Oiling out, Onset temperature, Propanoate, Racemic mixtures, Structural evolution, Ternary phase diagrams
National Category
Chemical Process Engineering
URN: urn:nbn:se:kth:diva-87891DOI: 10.1021/cg100605tISI: 000281353900026OAI: diva2:502024
QC 20120215Available from: 2012-02-14 Created: 2012-02-14 Last updated: 2012-02-15Bibliographically approved

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Bäbler, Matthäus
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