Ill-Conditioning: A Property of Bio Networks
2008 (English)In: Proceedings of 2nd q-Bio Conference on Cellular Information Processing, 2008, 2008Conference paper (Refereed)
Analysis of large gene expression datasetsshows that they all share the same feature; the variance isconcentrated to significantly fewer orthogonal directions thanthe applied perturbations span. Given that all perturbationsare of same magnitude, this shows that the underlyingnetworks are ill-conditioned. We establish ill-conditioning as ageneric property of biochemical networks, resulting from thefact that all networks need to provide both signal amplificationand disturbance attenuation. One consequence of illconditioningis the commonly observed co-expression of genes.
Place, publisher, year, edition, pages
Control Engineering Bioinformatics and Systems Biology
IdentifiersURN: urn:nbn:se:kth:diva-88879OAI: oai:DiVA.org:kth-88879DiVA: diva2:502531
2nd q-Bio Conference on Cellular Information Processing. Santa Fe, New Mexico, USA. August 6-9, 2008
QC 201205082012-02-142012-02-142012-05-08Bibliographically approved