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Ill-Conditioning: A Property of Bio Networks
KTH, School of Electrical Engineering (EES), Automatic Control.
KTH, School of Electrical Engineering (EES), Automatic Control.
2008 (English)In: Proceedings of 2nd q-Bio Conference on Cellular Information Processing, 2008, 2008Conference paper, Published paper (Refereed)
Abstract [en]

Analysis of large gene expression datasetsshows that they all share the same feature; the variance isconcentrated to significantly fewer orthogonal directions thanthe applied perturbations span. Given that all perturbationsare of same magnitude, this shows that the underlyingnetworks are ill-conditioned. We establish ill-conditioning as ageneric property of biochemical networks, resulting from thefact that all networks need to provide both signal amplificationand disturbance attenuation. One consequence of illconditioningis the commonly observed co-expression of genes.

Place, publisher, year, edition, pages
2008.
National Category
Control Engineering Bioinformatics and Systems Biology
Identifiers
URN: urn:nbn:se:kth:diva-88879OAI: oai:DiVA.org:kth-88879DiVA: diva2:502531
Conference
2nd q-Bio Conference on Cellular Information Processing. Santa Fe, New Mexico, USA. August 6-9, 2008
Note
QC 20120508Available from: 2012-02-14 Created: 2012-02-14 Last updated: 2012-05-08Bibliographically approved

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