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A Fluid-chemical model of thrombus formation
KTH, School of Engineering Sciences (SCI), Solid Mechanics (Dept.), Biomechanics.
KTH, School of Engineering Sciences (SCI), Solid Mechanics (Dept.), Biomechanics.
2011 (English)In: CMBE2011: 2nd International Conference on Mathematical and Computational Biomedical Engineering / [ed] P. Nithiarasu, R. Löhner, 2011Conference paper, Published paper (Refereed)
Abstract [en]

Our understanding of the genesis and evolution of Abdominal Aortic Aneurysms (AAAs), withparticular emphasis on Intra-Luminal Thrombus’ evolution, may be improved by studying thecomplex interplay between fluid-dynamics and biochemistry. To investigate the evolution of prothromboticchemicals inside the blood flow, in particular thrombin (factor IIa), a fluido-chemicalmodel has been developed. To this end a series of convection-diffusion-reaction (CDR) equationsdescribing the tissue factor pathway to thrombin have been solved on top of the biofluiddynamics problem. The proposed model integrates biochemistry and fluids dynamics, and hence,supports a comprehensive understanding of how ILT in AAAs may develop.

Place, publisher, year, edition, pages
2011.
Keyword [en]
Intra-luminal thrombus, coagulation cascade, CFD, convection-diffusion-reaction equations
National Category
Medical Engineering
Identifiers
URN: urn:nbn:se:kth:diva-89128OAI: oai:DiVA.org:kth-89128DiVA: diva2:502730
Conference
2nd International Conference on Mathematical and Computational Biomedical Engineering, Washington D.C., USA, March 30 – April 1, 2011
Funder
Swedish Research Council, 2006-7568
Note
QC 20120410Available from: 2012-02-14 Created: 2012-02-14 Last updated: 2012-04-10Bibliographically approved

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http://www-old.hallf.kth.se/~tg/vascumech/files/JB_TCG_compbiomed.pdf

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