Novelty: A biological system comprises substrate, channels (16) provided on substrate, fluid moving along channel in laminar flow and including suspended particles (20), pumping element driving laminar flow of fluid, detector, tagging system. The fluid, channel, and pumping element are configured to cause inertial forces to act on particles and to focus particles into stream lines. The channel has hydraulic diameter. Moving the fluid suspension focuses particles into localized streams. Location of focused stream channel depends on inertial forces and Dean drag forces acting on particles.Use: A system for focusing, sorting, and separating target particles (claimed) useful in industrial application including chemical process and fermentation filtration, water purification and wastewater treatment; in biomedical application including counting, sorting and filtering blood components and preparing safely sized micro-bubble ultrasound contrast agents; in research including tissue engineering, drug control release mechanism studies, cell signaling studies, protein crystallization, virus/bacteria capture, nucleic acid purification, and chemistry specific extractions; in the development of cosmetics, lubricants, pigments, environmental monitoring for particulates, natural oil extraction, particle synthesis, and polymer bead manufacturing; and in agriculture including development of multi-phase fertilizer emulsions, multi-phase pesticide emulsions, flow cytometry, and in hematology analysis.Advantage: The system can perform rapid continuous processing of samples without the need for filters or mechanical or electrical parts, high throughput applications, low noise results, and independence in focusing for particle shape and density. The inertial focusing of the system results in precise particle positioning into single stream and controlled longitudinal spacing between particles. Precise control of particle streamlines allows sorting with small induced changes in particle position. The system has the ability to perform cell ordering and separation at the point of care without the need for bulky equipment. The system also creates opportunities for rapid screening of patients for a number of diseases.
JP05172946B2 (2013-03-27); CN101765762B (2013-08-14); US8784012B2 (2014-07-22); US8807879B2 (2014-08-19)