Domino Carbopalladation-Carbonylation: Investigation of Substrate Scope
2012 (English)In: Advanced Synthesis and Catalysis, ISSN 1615-4150, E-ISSN 1615-4169, Vol. 354, no 1, 205-216 p.Article in journal (Refereed) Published
This work gives an in depth account of our domino carbopalladation-carbonylation method for substrates possessing beta-hydrogens. The scope of the method is examined for allylic amines containing trisubstituted olefins and we detail our attempts toward the diastereospecific synthesis of contiguous quaternary centers using this technology. The results give key insights into the relative rates of the competing reactions of the alkyl palladium intermediates, which is crucial for the understanding and development of new domino processes.
Place, publisher, year, edition, pages
2012. Vol. 354, no 1, 205-216 p.
carbonylation, domino reactions, Heck reaction, oxindoles, quaternary stereocenters
IdentifiersURN: urn:nbn:se:kth:diva-90663DOI: 10.1002/adsc.201100678ISI: 000299331300020ScopusID: 2-s2.0-84856833104OAI: oai:DiVA.org:kth-90663DiVA: diva2:506209
FunderKnut and Alice Wallenberg FoundationSwedish Research Council
QC 201202282012-02-282012-02-272012-06-11Bibliographically approved