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Anti-schistosomiasis triterpene glycoside from the Egyptian medicinal plant Asparagus stipularis
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2011 (English)In: REV BRAS FARMACOGN, ISSN 0102-695X, Vol. 22, no 2, 314-318 p.Article in journal (Refereed) Published
Abstract [en]

Bioassay-guided isolation using an in vitro assay testing for anti-schistosomiasis yielded a novel triterpene saponin, asparagalin A, from the n-butanol extract of the roots of Asparagus stipularis Forssk., Asparagaceae. The structure was elucidated by spectroscopic analysis and chemical transformations. Administration of asparagalin A resulted in a retardation of worm growth and locomotion at the first day and showed a significant activity of egg-laying suppression at 200 mu g/mL concentration.

Place, publisher, year, edition, pages
SOC BRASILEIRA FARMACOGNOSIA , 2011. Vol. 22, no 2, 314-318 p.
Keyword [en]
anti-schistosomiasis, Asparagus stipularis, Asparagaceae, triterpene glycoside
National Category
Pharmacology and Toxicology Medicinal Chemistry
URN: urn:nbn:se:kth:diva-90927DOI: 10.1590/S0102-695X2012005000004ISI: 000299742200010ScopusID: 2-s2.0-84856918267OAI: diva2:507529
QC 20120305Available from: 2012-03-05 Created: 2012-03-05 Last updated: 2012-03-05Bibliographically approved

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El-Seedi, Hesham R.Azeem, MuhammadBorg-Karlson, Anna-Karin
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