Simulation of HyperSPECT: a high-resolution small-animal system with in-line x-ray optics
2012 (English)In: Physics in Medicine and Biology, ISSN 0031-9155, E-ISSN 1361-6560, Vol. 57, no 6, 1617-1629 p.Article in journal (Refereed) Published
SPECT has become an important tool in pre-clinical applications. Small-animal imaging systems based on the use of one or more pinhole collimators now reach sub-half-mm resolution but unfortunately suffer from a compromise between sensitivity and resolution due to the pinhole collimators. We propose a small-animal SPECT system based not on pinholes but on in-line x-ray optics, which is rare in medical imaging systems for nuclear medicine. The x-ray lenses are optimized for 27 keV for low-energy imaging with iodine-125. We believe that this new system, HyperSPECT, can simultaneously improve on sensitivity and resolution compared to today's state-of-the-art systems. A full three-dimensional simulation of the system has been performed including the prism-array lenses, pre-and post-collimators and scintillator-based detector. Images of capillary phantoms have been reconstructed using an iterative image reconstruction method. Sensitivity was uniformly 0.37% throughout the 1 cm diameter spherical field of view and rod sizes of around 100 mu m diameter were distinguishable in the images of simulated capillary phantoms. These results indicate an increase in resolution by a factor of 5 during a simultaneous increase in sensitivity by a factor of 2 compared to the current state-of-the-art small-animal SPECT systems.
Place, publisher, year, edition, pages
2012. Vol. 57, no 6, 1617-1629 p.
Radiology, Nuclear Medicine and Medical Imaging
IdentifiersURN: urn:nbn:se:kth:diva-93382DOI: 10.1088/0031-9155/57/6/1617ISI: 000301358000010ScopusID: 2-s2.0-84858062493OAI: oai:DiVA.org:kth-93382DiVA: diva2:515915
QC 201204162012-04-162012-04-162013-12-18Bibliographically approved