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Simulation of HyperSPECT: a high-resolution small-animal system with in-line x-ray optics
KTH, School of Engineering Sciences (SCI), Physics, Physics of Medical Imaging.
KTH, School of Engineering Sciences (SCI), Physics, Physics of Medical Imaging.ORCID iD: 0000-0002-7725-0548
KTH, School of Engineering Sciences (SCI), Physics, Physics of Medical Imaging.ORCID iD: 0000-0002-3039-9791
2012 (English)In: Physics in Medicine and Biology, ISSN 0031-9155, E-ISSN 1361-6560, Vol. 57, no 6, 1617-1629 p.Article in journal (Refereed) Published
Abstract [en]

SPECT has become an important tool in pre-clinical applications. Small-animal imaging systems based on the use of one or more pinhole collimators now reach sub-half-mm resolution but unfortunately suffer from a compromise between sensitivity and resolution due to the pinhole collimators. We propose a small-animal SPECT system based not on pinholes but on in-line x-ray optics, which is rare in medical imaging systems for nuclear medicine. The x-ray lenses are optimized for 27 keV for low-energy imaging with iodine-125. We believe that this new system, HyperSPECT, can simultaneously improve on sensitivity and resolution compared to today's state-of-the-art systems. A full three-dimensional simulation of the system has been performed including the prism-array lenses, pre-and post-collimators and scintillator-based detector. Images of capillary phantoms have been reconstructed using an iterative image reconstruction method. Sensitivity was uniformly 0.37% throughout the 1 cm diameter spherical field of view and rod sizes of around 100 mu m diameter were distinguishable in the images of simulated capillary phantoms. These results indicate an increase in resolution by a factor of 5 during a simultaneous increase in sensitivity by a factor of 2 compared to the current state-of-the-art small-animal SPECT systems.

Place, publisher, year, edition, pages
2012. Vol. 57, no 6, 1617-1629 p.
National Category
Radiology, Nuclear Medicine and Medical Imaging
Identifiers
URN: urn:nbn:se:kth:diva-93382DOI: 10.1088/0031-9155/57/6/1617ISI: 000301358000010Scopus ID: 2-s2.0-84858062493OAI: oai:DiVA.org:kth-93382DiVA: diva2:515915
Note

QC 20120416

Available from: 2012-04-16 Created: 2012-04-16 Last updated: 2017-12-07Bibliographically approved
In thesis
1. HyperSPECT: a new instrument for high resolution single photon emission computed tomography
Open this publication in new window or tab >>HyperSPECT: a new instrument for high resolution single photon emission computed tomography
2013 (English)Licentiate thesis, comprehensive summary (Other academic)
Place, publisher, year, edition, pages
Stockholm: KTH Royal Institute of Technology, 2013. vi, 24 p.
Series
Trita-FYS, ISSN 0280-316X ; 2013:63
National Category
Radiology, Nuclear Medicine and Medical Imaging
Identifiers
urn:nbn:se:kth:diva-138301 (URN)978-91-7501-946-8 (ISBN)
Presentation
2013-12-13, Sal A2:1003, AlbaNova Universitetcentrum, Roslagstullsbacken 21, Stockholm, 13:00
Opponent
Supervisors
Note

QC 20131218

Available from: 2013-12-18 Created: 2013-12-18Bibliographically approved

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Nillius, Peter

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