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Mechanics, mechanobiology, and modeling of human abdominal aorta and aneurysms
KTH, School of Engineering Sciences (SCI), Solid Mechanics (Dept.).
2012 (English)In: Journal of Biomechanics, ISSN 0021-9290, E-ISSN 1873-2380, Vol. 45, no 5, 805-814 p.Article, review/survey (Refereed) Published
Abstract [en]

Biomechanical factors play fundamental roles in the natural history of abdominal aortic aneurysms (AAAs) and their responses to treatment. Advances during the past two decades have increased our understanding of the mechanics and biology of the human abdominal aorta and AAAs, yet there remains a pressing need for considerable new data and resulting patient-specific computational models that can better describe the current status of a lesion and better predict the evolution of lesion geometry, composition, and material properties and thereby improve interventional planning. In this paper, we briefly review data on the structure and function of the human abdominal aorta and aneurysmal wall, past models of the mechanics, and recent growth and remodeling models. We conclude by identifying open problems that we hope will motivate studies to improve our computational modeling and thus general understanding of AAAs.

Place, publisher, year, edition, pages
2012. Vol. 45, no 5, 805-814 p.
Keyword [en]
Wall stress, Growth, Remodeling, Finite elements, Hemodynamics
National Category
URN: urn:nbn:se:kth:diva-93932DOI: 10.1016/j.jbiomech.2011.11.021ISI: 000302040800011ScopusID: 2-s2.0-84857650183OAI: diva2:524842
QC 20120504Available from: 2012-05-04 Created: 2012-05-03 Last updated: 2012-05-04Bibliographically approved

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Holzapfel, Gerhard A.
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