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Standard Guidelines for the Chromosome-Centric Human Proteome Project
KTH, School of Biotechnology (BIO), Proteomics.ORCID iD: 0000-0001-8993-048X
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2012 (English)In: Journal of Proteome Research, ISSN 1535-3893, E-ISSN 1535-3907, Vol. 11, no 4, 2005-2013 p.Article in journal (Refereed) Published
Abstract [en]

The objective of the international Chromosome-Centric Human Proteome Project (C-HPP) is to map and annotate all proteins encoded by the genes on each human chromosome. The C-FIPP consortium was established to organize a collaborative network among the research teams responsible for protein mapping of individual chromosomes and to identify compelling biological and genetic mechanisms influencing colocated genes and their protein products. The C-HPP aims to foster the development of proteome analysis and integration of the findings from related molecular -omics technology platforms through collaborations among universities, industries, and private research groups. The C-HPP consortium leadership has elicited broad input for standard guidelines to manage these international efforts more efficiently by mobilizing existing resources and collaborative networks. The C-HPP guidelines set out the collaborative consensus of the C-HPP teams, introduce topics associated with experimental approaches, data production, quality control, treatment, and transparency of data, governance of the consortium, and collaborative benefits. A companion approach for the Biology and Disease-Driven HPP (B/D-HPP) component of the Human Proteome Project is currently being organized, building upon the Human Proteome Organization's organ-based and biofluid-based initiatives ( The common application of these guidelines in the participating laboratories is expected to facilitate the goal of a comprehensive analysis of the human proteome.

Place, publisher, year, edition, pages
2012. Vol. 11, no 4, 2005-2013 p.
Keyword [en]
antibody, Biology/Disease-Driven Human Proteome Project, Chromosome-Centric Human Proteome Project, Human Genome Project, Human Proteome Project, Human Proteome Organization, knowledge-base, mass spectrometry
National Category
Biochemistry and Molecular Biology
URN: urn:nbn:se:kth:diva-93926DOI: 10.1021/pr200824aISI: 000302388100001PubMedID: 22443261ScopusID: 2-s2.0-84859622404OAI: diva2:525134
QC 20120507Available from: 2012-05-07 Created: 2012-05-03 Last updated: 2012-05-07Bibliographically approved

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