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LytA, Major Autolysin of Streptococcus pneumoniae, Requires Access to Nascent Peptidoglycan
KTH, School of Engineering Sciences (SCI), Applied Physics, Experimental Biomolecular Physics.
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2012 (English)In: Journal of Biological Chemistry, ISSN 0021-9258, E-ISSN 1083-351X, Vol. 287, no 14, 11018-11029 p.Article in journal (Refereed) Published
Abstract [en]

Background: The regulation of cell wall hydrolysis by the pneumococcal autolysin LytA is poorly understood. Results: The cell wall is susceptible to extracellular LytA only during the stationary phase or after cell wall synthesis inhibition. Conclusion: LytA is regulated on the substrate level, where peptidoglycan modifications likely prevent LytA hydrolysis. Significance: The control of amidases is essential for bacterial survival, cell-wall synthesis, and division.

Place, publisher, year, edition, pages
2012. Vol. 287, no 14, 11018-11029 p.
Keyword [en]
Amidase, Biological approach, Cell wall synthesis, Cell walls, Choline binding domain, Exponential growth, Extracellular, Extracellular concentration, Nutrient depletion, Peptidoglycans, Potential substrate, Sensitized cells, Stationary phase, Streptococcus pneumoniae, Threshold concentrations, Virulence factors
National Category
Biochemistry and Molecular Biology
URN: urn:nbn:se:kth:diva-95120DOI: 10.1074/jbc.M111.318584ISI: 000302780100030ScopusID: 2-s2.0-84859483346OAI: diva2:526806
Swedish Research CouncilScience for Life Laboratory - a national resource center for high-throughput molecular bioscience

QC 20120515

Available from: 2012-05-15 Created: 2012-05-14 Last updated: 2013-04-15Bibliographically approved

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Rönnlund, DanielBlom, HansWidengren, Jerker
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