Cyanoethylation of the glucans dextran and pullulan: Substitution pattern and formation of nanostructures and entrapment of magnetic nanoparticles
2012 (English)In: Beilstein Journal of Organic Chemistry, ISSN 1860-5397, Vol. 8, 551-566 p.Article in journal (Refereed) Published
Cyanoethylglucans with a degree of substitution in the range of 0.74 to 2.40 for dextran and 0.84 to 2.42 for pullulan were obtained by Michael addition of acrylonitrile to the glucans under various conditions. Products were thoroughly characterized, comprising elementary analysis, NMR and ATR-IR spectroscopy, and analysis of the substituent distribution in the glucosyl units by GC-FID and GC-MS of the constituting monosaccharide derivatives. Nanostructuring of the highly substituted cyanoethylpolysaccharides was performed by dialysis against a non-solvent. In the presence of ferromagnetic iron-oxide nanoparticles, multicore cyanoethylglucan-coated ferromagnetic nanoparticles were formed by selective entrapment. The specific interaction between cyano groups and iron could be proven. The size distribution and morphology of the nanoparticles were analyzed by dynamic light scattering (DLS), scanning electron microscopy (SEM) and energy-filtered transmission electron microscopy (EF-TEM) with parallel electron energy loss spectroscopy (PEELS).
Place, publisher, year, edition, pages
2012. Vol. 8, 551-566 p.
cyanoethyldextran, cyanoethylpullulan, ferromagnetic nanoparticles, glycan nanostructures, substitution pattern
IdentifiersURN: urn:nbn:se:kth:diva-95101DOI: 10.3762/bjoc.8.63ISI: 000302895600001ScopusID: 2-s2.0-84859878720OAI: oai:DiVA.org:kth-95101DiVA: diva2:527733
QC 201205222012-05-222012-05-142012-05-22Bibliographically approved