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Oxadiazole isomers: all bioisosteres are not created equal
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2012 (English)In: MedChemComm, ISSN 2040-2503, E-ISSN 2040-2511, Vol. 3, no 5, 600-604 p.Article in journal (Refereed) Published
Abstract [en]

Two series of amino-substituted 1,2,4- and 1,3,4-oxadiazole matched compounds were evaluated and found to have significant differences in their various physical and pharmaceutical properties. Experimental and computational techniques suggested that variation in hydrogen bond acceptor and donor strength were responsible for these effects.

Place, publisher, year, edition, pages
2012. Vol. 3, no 5, 600-604 p.
Keyword [en]
article, drug half life, drug protein binding, drug solubility, drug stability, drug structure, drug synthesis, human, hydrogen bond, isomer, lipophilicity, mouse, nonhuman, plasma protein binding, priority journal, rat, structure analysis, substitution reaction
National Category
Biochemistry and Molecular Biology
Identifiers
URN: urn:nbn:se:kth:diva-98021DOI: 10.1039/c2md20054fISI: 000304387300010Scopus ID: 2-s2.0-84860429692OAI: oai:DiVA.org:kth-98021DiVA: diva2:535006
Note
QC 20120619Available from: 2012-06-19 Created: 2012-06-18 Last updated: 2017-12-07Bibliographically approved

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